Evidence map›Paper›PMID 36499492›Full record

ArticleInternational journal of molecular sciences2022

Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation.

Sunil Poudel, Gil Martins, M Leonor Cancela, Paulo J Gavaia

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Antimetastatic Effects of aAntioxidants (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sunil PoudelCentre of Marine Sciences, University of Algarve, 8005-139 Faro, Portugal.
Gil MartinsCentre of Marine Sciences, University of Algarve, 8005-139 Faro, Portugal.ORCID 0000-0002-1344-2954
M Leonor CancelaCentre of Marine Sciences, University of Algarve, 8005-139 Faro, Portugal.ORCID 0000-0003-3114-6662
Paulo J GavaiaCentre of Marine Sciences, University of Algarve, 8005-139 Faro, Portugal.ORCID 0000-0002-9582-1957
University of Algarve · PTAlgarve Biomedical Center · PT

Funding

European Commission 766347- BioMedAquFundação para a Ciência e Tecnologia LA/P/0101/2020Fundação para a Ciência e Tecnologia UIDB/04326/2020Fundação para a Ciência e Tecnologia UIDP/04326/2020
6 · The paper itself

Abstract

Secondary osteoporosis has been associated with cancer patients undertaking Doxorubicin (DOX) chemotherapy. However, the molecular mechanisms behind DOX-induced bone loss have not been elucidated. Molecules that can protect against the adverse effects of DOX are still a challenge in chemotherapeutic treatments. We investigated the effect and mechanism of DOX in osteoclast differentiation and used the

Indexed as

Bone ResorptionZebrafishAnimalsAntioxidantsCell DifferentiationDoxorubicinNFATC Transcription FactorsOsteoclastsOsteogenesisRANK LigandResveratrolAntioxidantsDoxorubicinNFATC Transcription FactorsRANK LigandResveratroldoxorubicinMitoTEMPOosteoclast differentiationoxidative stressresveratrolsecondary osteoporosis

Identifiers

PMID36499492
PMCPMC9738652
OpenAlexW4311101927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.