ArticleInternational journal of molecular sciences2022
Use of CGF in Oral and Implant Surgery: From Laboratory Evidence to Clinical Evaluation.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Efficacy of concentrated growth factor compared with other types of regenerative endodontic procedures: a systematic review.BMC oral health · 2025Pooled it
- Paediatric dental trauma: insights from epidemiological studies and management recommendations.BMC oral health · 2025Pooled it
- Specific gene expression patterns associated as reliable biomarkers for predicting dental implant successful osseointegration: a literature review and focused meta-analysis.Frontiers in physiology · 2025Pooled it
- Application of sticky bone combined with concentrated growth factor (CGF) for horizontal alveolar ridge augmentation of anterior teeth: a randomized controlled clinical study.BMC oral health · 2024Trial
- A study on the osteogenic effect of CGF membrane combined with bone graft in rabbit calvarial defects.BMC oral health · 2026Article
- Socket-Shield Technique and Concentrated Growth Factors for Implant Placement in the Esthetic Zone: A Two-Year Case Report.Clinical case reports · 2026Article
- Evolution and mechanistic insights of platelet-derived products in temporomandibular joint regeneration.Frontiers in cell and developmental biology · 2026Review
- Investigation of attachment and proliferation of MG-63 osteoblast-like cells to titanium disks in the presence of iPRF (injectable platelet-rich fibrin) or CGF (Concentrated Growth Factor): A laboratory study.Journal of advanced periodontology & implant dentistry · 2026Article
- Porous tantalum cage loaded with CGF promotes interbody fusion in a rat XLIF model.Scientific reports · 2025Article
- CGF-Conditioned Medium Modulates Astrocytic Differentiation and Invasiveness in U87MG Glioblastoma Cells.Biology · 2025Article
- Cells Derived from Concentrated Growth Factor Exhibit a Multilineage Differentiation Capacity.International journal of molecular sciences · 2025Article
- Applications of Growth Factors in Implant Dentistry.Current issues in molecular biology · 2025Review
- Parameter optimization of femtosecond laser pulses for implant cavity preparation.Biomedical optics express · 2025Article
- Concentrated Growth Factors and Bone Grafting in Maxillary Sinus Lift: A Systematic Review.International journal of dentistry · 2025Review
- The effects of mineral trioxide aggregate and second-generation autologous growth factor on pulpotomy via TNF-α and NF-kβ/p65 pathways.BMC oral health · 2024Article
- Concentrated growth factor and collagen as barrier materials in alveolar ridge preservation for posterior teeth: a prospective cohort study with one-year follow-up.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024Article
- The Role of Sulfhydryl (Thiols) Groups in Oral and Periodontal Diseases.Biomedicines · 2024Article
- Neurological Complications following Surgical Treatments of the Lower Molars.International journal of dentistry · 2024Review
- Application of Graphene Oxide in Oral Surgery: A Systematic Review.Materials (Basel, Switzerland) · 2023Review
- Mesenchymal Stem Cells Derived from Human Periapical Cysts and Their Implications in Regenerative Medicine.Biomedicines · 2023Review
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 3 countries.
Funding
Abstract
Edentulism is the condition of having lost natural teeth, and has serious social, psychological, and emotional consequences. The need for implant services in edentulous patients has dramatically increased during the last decades. In this study, the effects of concentrated growth factor (CGF), an autologous blood-derived biomaterial, in improving the process of osseointegration of dental implants have been evaluated. Here, permeation of dental implants with CGF has been obtained by using a Round up device. These CGF-coated dental implants retained a complex internal structure capable of releasing growth factors (VEGF, TGF-β1, and BMP-2) and matrix metalloproteinases (MMP-2 and MMP-9) over time. The CGF-permeated implants induced the osteogenic differentiation of human bone marrow stem cells (hBMSC) as confirmed by matrix mineralization and the expression of osteogenic differentiation markers. Moreover, CGF provided dental implants with a biocompatible and biologically active surface that significantly improved adhesion of endothelial cells on CGF-coated implants compared to control implants (without CGF). Finally, data obtained from surgical interventions with CGF-permeated dental implants presented better results in terms of optimal osseointegration and reduced post-surgical complications. These data, taken together, highlight new and interesting perspectives in the use of CGF in the dental implantology field to improve osseointegration and promote the healing process.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.