ReviewInternational journal of molecular sciences2022
The Intestinal Immune Defense System in Insects.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 66 citations in OpenAlex.
- Article
- Knockouts of Sulfur Metabolism Genes Induce Chronic Inflammation and Immune Dysregulation inAntioxidants (Basel, Switzerland) · 2026Article
- When Small Meets Smaller: Immune Modulation and Virulence Strategies in Insect-Bacteria Interactions.Insects · 2026Review
- Probiotic Modulation of Gut Microbiota Enhances Immunity and Nutrition in SIT Ceratitis Capitata Sterile Males.Microbial ecology · 2026Article
- Tissue- and time-dependent modulation of JAK/STAT pathway genes in Tenebrio molitor during Listeria monocytogenes infection.World journal of microbiology & biotechnology · 2026Article
- Internal Microbiota Guided Stage Selection in Two Swine-Manure Bioconversion Flies for Feed-Protein Harvest.Insects · 2026Article
- Pharmacological Effects of NADPH Oxidase Inhibitors on Butterfly Wing Morphogenesis and Color Pattern Formation inInsects · 2026Article
- Effect of mixed infection with Trypanosoma cruzi and the fungus Metarhizium anisopliae on survival, parasitemia, and immune response in Triatoma pallidipennis (Hemiptera: Reduviidae).Journal of medical entomology · 2026Article
- Host intestinal microbiota adaptive changes following Paranosema locustae infection and mechanism of chronic pathogenesis.Journal of insect science (Online) · 2026Article
- Ecological origin and naturalCurrent research in parasitology & vector-borne diseases · 2026Article
- Immunological responses and gut microbial shift of fall armywormFrontiers in microbiology · 2026Article
- Chemical modulation of IMD signaling in the cat flea (Current research in insect science · 2026Article
- Harnessing Edible Insect Bioactives for Gut Health: A Comprehensive Review on Chitin-Derived Prebiotics and Peptidomic Insights from the Black Soldier Fly.Foods (Basel, Switzerland) · 2025Review
- The Microbiome as a Protagonist of Xylophagous Insects in Adaptation to Environmental Conditions and Climate Change.International journal of molecular sciences · 2025Review
- Comparative Transcriptome Analysis ofInsects · 2025Article
- Article
- Pathogen-induced damage in Drosophila: Uncoupling disease tolerance from resistance.PLoS pathogens · 2025Article
- Review
- Investigating the Microbial Dynamics ofFoods (Basel, Switzerland) · 2025Article
- The immune response of Phytoseiulus persimilis (Acari: Phytoseiidae) to the bacterial pathogen Acaricomes phytoseiuli.Experimental & applied acarology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over a long period of evolution, insects have developed unique intestinal defenses against invasion by foreign microorganisms, including physical defenses and immune responses. The physical defenses of the insect gut consist mainly of the peritrophic matrix (PM) and mucus layer, which are the first barriers to pathogens. Gut microbes also prevent the colonization of pathogens. Importantly, the immune-deficiency (Imd) pathways produce antimicrobial peptides to eliminate pathogens; mechanisms related to reactive oxygen species are another important pathway for insect intestinal immunity. The janus kinase/STAT signaling pathway is involved in intestinal immunity by producing bactericidal substances and regulating tissue repair. Melanization can produce many bactericidal active substances into the intestine; meanwhile, there are multiple responses in the intestine to fight against viral and parasitic infections. Furthermore, intestinal stem cells (ISCs) are also indispensable in intestinal immunity. Only the coordinated combination of the intestinal immune defense system and intestinal tissue renewal can effectively defend against pathogenic microorganisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.