Evidence map›Paper›PMID 36499438›Full record

Observational studyInternational journal of molecular sciences2022

Comparison of Body Composition, Muscle Strength and Cardiometabolic Profile in Children with Prader-Willi Syndrome and Non-Alcoholic Fatty Liver Disease: A Pilot Study.

Diana R Mager, Krista MacDonald, Reena L Duke, Hayford M Avedzi, Edward C Deehan, Jason Yap, Kerry Siminoski, Andrea M Haqq

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Diana R MagerDepartment of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Krista MacDonaldDepartment of Agricultural Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Reena L DukeDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Hayford M AvedziDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0003-1854-3364
Edward C DeehanDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0001-7697-1418
Jason YapDepartment of Paediatrics, University of Melbourne, Melbourne, VIC 3010, Australia.ORCID 0000-0003-2466-6969
Kerry SiminoskiFaculty of Medicine and Dentistry, Radiology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Andrea M HaqqDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.
University of Alberta · CAThe University of Melbourne · AU

Funding

Food and Health Innovation Initiative, University of Alberta 000The Wirtanen Graduate Scholarship, Alberta Diabetes Institute 000Vitamin Fund, Department of Department of Agricultural Food and Nutritional Sciences, Univer-sity of Alberta 000Women and Children's Health Research Institute Graduate Scholarship, University of Alberta 000
6 · The paper itself

Abstract

Syndromic and non-syndromic obesity conditions in children, such as Prader-Willi syndrome (PWS) and non-alcoholic fatty liver disease (NAFLD), both lower quality of life and increase risk for chronic health complications, which further increase health service utilization and cost. In a pilot observational study, we compared body composition and muscle strength in children aged 7−18 years with either PWS (n = 9), NAFLD (n = 14), or healthy controls (n = 16). Anthropometric and body composition measures (e.g., body weight, circumferences, skinfolds, total/segmental composition, and somatotype), handgrip strength, six minute-walk-test (6MWT), physical activity, and markers of liver and cardiometabolic dysfunction (e.g., ALT, AST, blood pressure, glucose, insulin, and lipid profile) were measured using standard procedures and validated tools. Genotyping was determined for children with PWS. Children with PWS had reduced lean body mass (total/lower limb mass), lower handgrip strength, 6MWT and increased sedentary activity compared to healthy children or those with NAFLD (p < 0.05). Children with PWS, including those of normal body weight, had somatotypes consistent with relative increased adiposity (endomorphic) and reduced skeletal muscle robustness (mesomorphic) when compared to healthy children and those with NAFLD. Somatotype characterizations were independent of serum markers of cardiometabolic dysregulation but were associated with increased prevalence of abnormal systolic and diastolic blood pressure Z-scores (p < 0.05). Reduced lean body mass and endomorphic somatotypes were associated with lower muscle strength/functionality and sedentary lifestyles, particularly in children with PWS. These findings are relevant as early detection of deficits in muscle strength and functionality can ensure effective targeted treatments that optimize physical activity and prevent complications into adulthood.

Indexed as

Non-alcoholic Fatty Liver DiseasePrader-Willi SyndromeAdultBody CompositionBody Mass IndexChildHand StrengthHumansMuscle StrengthObesityPilot ProjectsQuality of Lifebody compositionchildrenmuscle strengthnon-alcoholic fatty liver diseasePrader-Willi syndrome

Identifiers

PMID36499438
PMCPMC9739027
OpenAlexW4311093575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.