Evidence map›Paper›PMID 36499401›Full record

SynthesisInternational journal of molecular sciences2022

Mesenchymal Stem Cells and Psoriasis: Systematic Review.

Federico Diotallevi, Mariangela Di Vincenzo, Emanuela Martina, Giulia Radi, Vincenzo Lariccia, Annamaria Offidani, Monia Orciani, Anna Campanati

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Federico DiotalleviDepartment of Clinical and Molecular Sciences, Dermatological Clinic, Università Politecnica delle Marche, 60126 Ancona, Italy.ORCID 0000-0003-2274-1742
Mariangela Di VincenzoHistology, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60126 Ancona, Italy.
Emanuela MartinaDepartment of Clinical and Molecular Sciences, Dermatological Clinic, Università Politecnica delle Marche, 60126 Ancona, Italy.
Giulia RadiDepartment of Clinical and Molecular Sciences, Dermatological Clinic, Università Politecnica delle Marche, 60126 Ancona, Italy.ORCID 0000-0003-3153-1026
Vincenzo LaricciaPharmacology, Department of Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60126 Ancona, Italy.ORCID 0000-0002-1518-1495
Annamaria OffidaniDepartment of Clinical and Molecular Sciences, Dermatological Clinic, Università Politecnica delle Marche, 60126 Ancona, Italy.
Monia OrcianiHistology, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, 60126 Ancona, Italy.ORCID 0000-0003-4503-3693
Anna CampanatiDepartment of Clinical and Molecular Sciences, Dermatological Clinic, Università Politecnica delle Marche, 60126 Ancona, Italy.ORCID 0000-0002-3740-0839
Marche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal Stem Cells (MSCs) are multipotent non-hematopoietic stromal cells found in different body tissues such as bone marrow, adipose tissue, periosteum, Wharton's jelly, umbilical cord, blood, placenta, amniotic fluid, and skin. The biological behavior of MSCs depends mainly on their interaction with the microenvironment in which they are found, whose quality deeply influences the regenerative and immunomodulatory properties of these cells. Several studies confirm the interaction between MSCs and inflammatory microenvironment in the pathogenesis of psoriasis, designating MSCs as an important factor driving psoriasis development. This review aims to describe the most recent evidence on how the inflammatory microenvironment that characterizes psoriasis influences the homeostasis of MSCs and how they can be used to treat the disease.

Indexed as

Mesenchymal Stem CellsWharton JellyAmniotic FluidCell DifferentiationFemaleHumansPregnancyUmbilical Cordbiologicsmesenchymal stem cellsmicroenvironmentpsoriasissmall moleculessystemic treatments

Identifiers

PMID36499401
PMCPMC9740222
OpenAlexW4311053319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.