Evidence map›Paper›PMID 36499396›Full record

ReviewInternational journal of molecular sciences2022

How Functional Lipids Affect the Structure and Gating of Mechanosensitive MscS-like Channels.

Vanessa Judith Flegler, Tim Rasmussen, Bettina Böttcher

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. The MscS channel frombioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Lipid Regulation of Mechanosensitive Ion Channels.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Biofilm · 2024
    Article
  9. Osmotic Pressure and Its Biological Implications.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vanessa Judith FleglerRudolf Virchow Center and Biocenter, University Würzburg, 97080 Würzburg, Germany.ORCID 0000-0003-3627-0603
Tim RasmussenRudolf Virchow Center and Biocenter, University Würzburg, 97080 Würzburg, Germany.ORCID 0000-0003-1126-846X
Bettina BöttcherRudolf Virchow Center and Biocenter, University Würzburg, 97080 Würzburg, Germany.ORCID 0000-0002-7962-4849

Funding

Deutsche Forschungsgemeinschaft Bo1150/15-1Deutsche Forschungsgemeinschaft Bo 1150/15-2
6 · The paper itself

Abstract

The ability to cope with and adapt to changes in the environment is essential for all organisms. Osmotic pressure is a universal threat when environmental changes result in an imbalance of osmolytes inside and outside the cell which causes a deviation from the normal turgor. Cells have developed a potent system to deal with this stress in the form of mechanosensitive ion channels. Channel opening releases solutes from the cell and relieves the stress immediately. In bacteria, these channels directly sense the increased membrane tension caused by the enhanced turgor levels upon hypoosmotic shock. The mechanosensitive channel of small conductance, MscS, from

Indexed as

Escherichia coli ProteinsBacteriaEscherichia coliIon ChannelsMechanotransduction, CellularMembranesOsmotic PressureEscherichia coli ProteinsIon ChannelsMscS protein, E colifunctional lipidslipid-protein interactionsmechanosensitiveMscS-like channels

Identifiers

PMID36499396
PMCPMC9739000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.