Evidence map›Paper›PMID 36499315›Full record

ReviewInternational journal of molecular sciences2022

Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes.

Yanru Ren, Lu Fan, Said Alkildani, Luo Liu, Steffen Emmert, Stevo Najman, Denis Rimashevskiy, Reinhard Schnettler, Ole Jung, Xin Xiong and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 1 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 1 synthesis or guideline pooled it, 181 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Comparative Analysis of Gelatin/Polylactic Acid and Commercial PLA Membranes for Guided Bone Regeneration: A Randomized Clinical Trial.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Natural Polymers in Guided Bone Regeneration (GBR).Journal of functional biomaterials · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Yanru RenClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.ORCID 0000-0001-6745-9471
Lu FanNMI Natural and Medical Sciences Institute, University of Tübingen, 72770 Reutlingen, Germany.
Said AlkildaniBerlinAnalytix GmbH, 12109 Berlin, Germany.
Luo LiuBeijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100013, China.ORCID 0000-0002-3542-8213
Steffen EmmertClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.
Stevo NajmanScientific Research Center for Biomedicine, Department for Cell and Tissue Engineering, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.ORCID 0000-0002-2411-9802
Denis RimashevskiyDepartment of Traumatology and Orthopedics, Peoples' Friendship University of Russia, 117198 Moscow, Russia.
Reinhard SchnettlerUniversity Medical Centre, Justus Liebig University of Giessen, 35390 Giessen, Germany.
Ole JungClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.ORCID 0000-0001-8005-2916
Xin XiongNMI Natural and Medical Sciences Institute, University of Tübingen, 72770 Reutlingen, Germany.ORCID 0000-0003-0902-7886
Mike BarbeckClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.ORCID 0000-0002-3001-1347
University of Rostock · DENatural and Medical Sciences Institute · DEBeijing University of Chemical Technology · CNJustus-Liebig-Universität Gießen · DEPeoples' Friendship University of Russia · RUUniversity of Nis · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guided bone regeneration (GBR) has become a clinically standard modality for the treatment of localized jawbone defects. Barrier membranes play an important role in this process by preventing soft tissue invasion outgoing from the mucosa and creating an underlying space to support bone growth. Different membrane types provide different biological mechanisms due to their different origins, preparation methods and structures. Among them, collagen membranes have attracted great interest due to their excellent biological properties and desired bone regeneration results to non-absorbable membranes even without a second surgery for removal. This work provides a comparative summary of common barrier membranes used in GBR, focusing on recent advances in collagen membranes and their biological mechanisms. In conclusion, the review article highlights the biological and regenerative properties of currently available barrier membranes with a particular focus on bioresorbable collagen-based materials. In addition, the advantages and disadvantages of these biomaterials are highlighted, and possible improvements for future material developments are summarized.

Indexed as

Guided Tissue RegenerationGuided Tissue Regeneration, PeriodontalBiocompatible MaterialsBone RegenerationCollagenMembranes, ArtificialPolytetrafluoroethyleneBiocompatible MaterialsCollagenMembranes, ArtificialPolytetrafluoroethyleneabsorbable membranebioactive factorcollagen sourcescrosslinkingimmune responsemacrophagespolytetrafluoroethylene (PTFE)titaniumvascularization

Identifiers

PMID36499315
PMCPMC9735671
OpenAlexW4310999220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.