Evidence map›Paper›PMID 36499238›Full record

ReviewInternational journal of molecular sciences2022

The Role of L-Arginine-NO System in Female Reproduction: A Narrative Review.

Jozsef Bodis, Balint Farkas, Bernadett Nagy, Kalman Kovacs, Endre Sulyok

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Effects of DietaryAnimals : an open access journal from MDPI · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Effect of equine-derivedFrontiers in microbiology · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jozsef BodisDepartment of Obstetrics and Gynecology, University of Pecs School of Medicine, 7624 Pécs, Hungary.
Balint FarkasDepartment of Obstetrics and Gynecology, University of Pecs School of Medicine, 7624 Pécs, Hungary.ORCID 0000-0003-0638-2057
Bernadett NagyDepartment of Obstetrics and Gynecology, University of Pecs School of Medicine, 7624 Pécs, Hungary.
Kalman KovacsDepartment of Obstetrics and Gynecology, University of Pecs School of Medicine, 7624 Pécs, Hungary.
Endre SulyokNational Laboratory on Human Reproduction, University of Pécs, 7622 Pécs, Hungary.
University of Pecs · HU

Funding

European Union GINOP-2.3.2-15-2016-00021
6 · The paper itself

Abstract

Accumulating evidence are available on the involvement of l-arginine-nitric oxide (NO) system in complex biological processes and numerous clinical conditions. Particular attention was made to reveal the association of l-arginine and methylarginines to outcome measures of women undergoing in vitro fertilization (IVF). This review attempts to summarize the expression and function of the essential elements of this system with particular reference to the different stages of female reproduction. A literature search was performed on the PubMed and Google Scholar systems. Publications were selected for evaluation according to the results presented in the Abstract. The regulatory role of NO during the period of folliculogenesis, oocyte maturation, fertilization, embryogenesis, implantation, placentation, pregnancy, and delivery was surveyed. The major aspects of cellular l-arginine uptake via cationic amino acid transporters (CATs), arginine catabolism by nitric oxide synthases (NOSs) to NO and l-citrulline and by arginase to ornithine, and polyamines are presented. The importance of NOS inhibition by methylated arginines and the redox-sensitive elements of the process of NO generation are also shown. The l-arginine-NO system plays a crucial role in all stages of female reproduction. Insufficiently low or excessively high rates of NO generation may have adverse influences on IVF outcome.

Indexed as

ArginineNitric OxideArginaseFemaleHumansNitric Oxide SynthaseOrnithinePregnancyArginaseArginineNitric OxideNitric Oxide SynthaseOrnithinefemale reproductionl-argininemethylargininesnitric oxideoxidative stress

Identifiers

PMID36499238
PMCPMC9735906
OpenAlexW4310182067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.