Evidence map›Paper›PMID 36499205›Full record

ArticleInternational journal of molecular sciences2022

Fc Gamma Receptor IIIB NA1/NA2/SH Polymorphisms Are Associated with Malaria Susceptibility and Antibody Levels to

Abdou Khadre Dit Jadir Fall, David Courtin, Rafiou Adamou, Sofie Edslev, Anita Hansen, Nadia Domingo, Michael Christiansen, Bright Adu, Jacqueline Milet, André Garcia and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Abdou Khadre Dit Jadir FallInstitut de Recherche pour le Développement, UMR 261 MERIT, Université Paris Cité, 75006 Paris, France.
David CourtinInstitut de Recherche pour le Développement, UMR 261 MERIT, Université Paris Cité, 75006 Paris, France.
Rafiou AdamouInstitut de Recherche pour le Développement, UMR 261 MERIT, Université Paris Cité, 75006 Paris, France.
Sofie EdslevCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Department of Infectious Diseases, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, 2300 Copenhagen, Denmark.
Anita HansenCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Department of Infectious Diseases, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, 2300 Copenhagen, Denmark.
Nadia DomingoInstitut de Recherche pour le Développement, UMR 261 MERIT, Université Paris Cité, 75006 Paris, France.
Michael ChristiansenDepartment for Congenital Disorders, Statens Serum Institut, 2300 Copenhagen, Denmark.ORCID 0000-0003-4713-755X
Bright AduCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Department of Infectious Diseases, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, 2300 Copenhagen, Denmark.
Jacqueline MiletInstitut de Recherche pour le Développement, UMR 261 MERIT, Université Paris Cité, 75006 Paris, France.
André GarciaInstitut de Recherche pour le Développement, UMR 261 MERIT, Université Paris Cité, 75006 Paris, France.ORCID 0000-0002-1808-472X
Michael TheisenCentre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Department of Infectious Diseases, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, 2300 Copenhagen, Denmark.
Florence Migot-NabiasInstitut de Recherche pour le Développement, UMR 261 MERIT, Université Paris Cité, 75006 Paris, France.ORCID 0000-0001-9982-594X
Célia DechavanneInstitut de Recherche pour le Développement, UMR 261 MERIT, Université Paris Cité, 75006 Paris, France.ORCID 0000-0001-8439-9976
Université Paris Cité · FRStatens Serum Institut · DKUniversity of Copenhagen · DK

Funding

Agence Nationale de la Recherche ANR TOLIMMUNPAL project
6 · The paper itself

Abstract

This paper aimed to investigate the influence of polymorphisms in the FCGR2A gene encoding R131H FcgRIIA variants and in the FCGR3B gene (108G > C, 114C > T, 194 A > G, 233C > A, 244 G > A and 316G > A) encoding FcgRIIIB-NA1, -NA2 and -SH variants on malaria susceptibility and antibody responses against P. falciparum merozoite antigens in Beninese children. An active malaria follow-up was conducted in infants from birth to 24 months of age in Allada, Benin. FCGR3B exon 3 was sequenced and FCGR2A exon 4 was genotyped. Antibodies directed to GLURP and MSP3 were quantified by ELISA. Association studies were performed using mixed-effect models. Individual carriage of FCGR3B 194 AA genotype was associated with a high number of malaria infections and a low level of IgG1 against MSP3 and GLURP-R0. High parasitemia and increased malaria infections were observed in infants carrying the FCGR3B*05 108C-114T-194A-233C-244A-316A haplotype. A reduced risk of malaria infections and low parasitemia were related to the carriages of the FCGR3B 108C-114T-194G-233C-244G-316A (FCGR3B*06), FCGR3B 108C−114T−194G−233A−244A−316A (FCGR3B*03 encoding for FcgRIIIB-SH) haplotypes and FCGR3B 297 TT genotype. Our results highlight the impact of FCGR3B polymorphisms on the individual susceptibility to malaria and antibody responses against MSP3 and GLURP in Beninese children.

Indexed as

MalariaMalaria, FalciparumAnimalsAntigens, ProtozoanChildHumansInfantMerozoitesPlasmodium falciparumPolymorphism, GeneticReceptors, IgGAntigens, ProtozoanReceptors, IgGantibody responseBeninFc gamma receptorFcgRIIIB-NA1malaria susceptibility-NA2-SH variants

Identifiers

PMID36499205
PMCPMC9739279
OpenAlexW4310211653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.