Evidence map›Paper›PMID 36499177›Full record

ArticleInternational journal of molecular sciences2022

Increased Prevalence of Unstable HLA-C Variants in HIV-1 Rapid-Progressor Patients.

Chiara Stefani, Antonella Sangalli, Elena Locatelli, Tania Federico, Giovanni Malerba, Maria Grazia Romanelli, Gustavo Adolfo Argañaraz, Bosco Christiano Maciel Da Silva, Alberto Jose Duarte Da Silva, Jorge Casseb and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chiara StefaniSection of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-2327-9772
Antonella SangalliSection of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-6359-0149
Elena LocatelliSection of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Tania FedericoSection of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Giovanni MalerbaSection of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-8705-8560
Maria Grazia RomanelliSection of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-7360-1195
Gustavo Adolfo ArgañarazLab of Molecular NeuroVirology, Faculty of Health Science, University of Brasília, Brasilia 70910-900, Brazil.
Bosco Christiano Maciel Da SilvaMedical Investigation Laboratory Unit 56 (LIM/56), Faculdade de Medicina FMUSP, University of São Paulo, São Paulo 05403-000, Brazil.ORCID 0000-0002-3883-7178
Alberto Jose Duarte Da SilvaMedical Investigation Laboratory Unit 56 (LIM/56), Faculdade de Medicina FMUSP, University of São Paulo, São Paulo 05403-000, Brazil.
Jorge CassebFaculty of Medicine, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403-000, Brazil.ORCID 0000-0002-4553-2559
Enrique Roberto ArgañarazLab of Molecular NeuroVirology, Faculty of Health Science, University of Brasília, Brasilia 70910-900, Brazil.ORCID 0000-0002-4359-7594
Alessandra RuggieroSection of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Donato ZipetoSection of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-2168-4144

Funding

Gilead Sciences (Italy) Gilead Fellowship Program 2019
6 · The paper itself

Abstract

HIV-1 infection in the absence of treatment results in progression toward AIDS. Host genetic factors play a role in HIV-1 pathogenesis, but complete knowledge is not yet available. Since less-expressed HLA-C variants are associated with poor HIV-1 control and unstable HLA-C variants are associated with higher HIV-1 infectivity, we investigated whether there was a correlation between the different stages of HIV-1 progression and the presence of specific HLA-C allotypes. HLA-C genotyping was performed using allele-specific PCR by analyzing a treatment-naïve cohort of 96 HIV-1-infected patients from multicentric cohorts in the USA, Canada, and Brazil. HIV-1-positive subjects were classified according to their different disease progression status as progressors (Ps,

Indexed as

Acquired Immunodeficiency SyndromeHIV-1HIV InfectionsDisease ProgressionHLA-C AntigensHumansHLA-C AntigensAIDS progressionASPCRHIV-1 infection controlHLA-C stabilityMHC class I

Identifiers

PMID36499177
PMCPMC9741376

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.