Evidence map›Paper›PMID 36499167›Full record

ArticleInternational journal of molecular sciences2022

Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Narirutin via Block of Na

Haoyi Yang, Zhiming Shan, Weijie Guo, Yuwei Wang, Shuxian Cai, Fuyi Li, Qiaojie Huang, Jessica Aijia Liu, Chi Wai Cheung, Song Cai

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Small-molecule natural product sophoricoside reduces peripheral neuropathic pain via directly blocking of NaV1.6 in dorsal root ganglion nociceptive neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Haoyi YangDepartment of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Zhiming ShanLaboratory and Clinical Research Institute for Pain, Department of Anaesthesiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0002-4575-3933
Weijie GuoDepartment of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Yuwei WangDepartment of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Shuxian CaiDepartment of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Fuyi LiDepartment of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Qiaojie HuangDepartment of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.
Jessica Aijia LiuDepartment of Neuroscience, City University of Hong Kong, Hong Kong 999077, China.
Chi Wai CheungLaboratory and Clinical Research Institute for Pain, Department of Anaesthesiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.
Song CaiDepartment of Anatomy and Histology, Shenzhen University Health Science Center, Shenzhen 518060, China.ORCID 0000-0003-1482-1291
Shenzhen University Health Science Center · CNChinese University of Hong Kong · HKCity University of Hong Kong · HKJinan University · CN

Funding

National Natural Science Foundation of China No.82001188Sanming Project of Medicine in Shenzhen No.SZSM202011021Science and Technology Planning Project of Shenzhen No.JCYJ20190807154401665 and No.JCYJ20180305163652073Shenzhen Key Medical Discipline Construction Fund No.SZXK044
6 · The paper itself

Abstract

Neuropathic pain is a refractory chronic disease affecting millions of people worldwide. Given that present painkillers have poor efficacy or severe side effects, developing novel analgesics is badly needed. The multiplex structure of active ingredients isolated from natural products provides a new source for phytochemical compound synthesis. Here, we identified a natural product, Narirutin, a flavonoid compound isolated from the

Indexed as

Biological ProductsNeuralgiaVoltage-Gated Sodium ChannelsAnalgesicsAnimalsGanglia, SpinalHEK293 CellsHumansNAV1.7 Voltage-Gated Sodium ChannelRatsRats, Sprague-DawleySensory Receptor CellsTetrodotoxinAnalgesicsBiological ProductsNAV1.7 Voltage-Gated Sodium ChannelTetrodotoxinVoltage-Gated Sodium Channelsion channelsNarirutinnatural productsNav1.7neuropathic painnociceptive neurons

Identifiers

PMID36499167
PMCPMC9738487
OpenAlexW4310375422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.