Detecting the Hydrogen Bond Cooperativity in a Protein β-Sheet by H/D Exchange.

Jingwen Li, Jingfei Chen, Yefei Wang, Lishan Yao

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 47% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Measurement of protein non-covalent interactions in buffer and cells.Magnetic resonance letters · 2025
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jingwen LiCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China.

Jingfei ChenQingdao New Energy Shandong Laboratory, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.

Yefei WangQingdao New Energy Shandong Laboratory, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.

Lishan YaoQingdao New Energy Shandong Laboratory, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.

Qingdao Institute of Bioenergy and Bioprocess Technology · CNChina University of Petroleum, East China · CNChinese Academy of Sciences · CN

Funding

Fundamental Research Funds for the Central Universities 21CX06014ANational Natural Science Foundation of China 31872725National Natural Science Foundation of China 32271268QIBEBT DICP&QIBEBT UN201802QIBEBT QIBEBT I201928Shandong Energy Institute SEI I202102Shandong Energy Institute SEI S202105Taishan Scholars Program of Shandong Province ts201712077

6 · The paper itself

Abstract

The hydrogen bond (H-bond) cooperativity in the β-sheet of GB3 is investigated by a NMR hydrogen/deuterium (H/D) exchange method. It is shown that the weakening of one backbone N-H…O=C H-bond between two β-strands, β1 and β2, due to the exchange of NH to ND of the H-bond donor in β1, perturbs the chemical shift of

Indexed as

HydrogenIsotopesHydrogen BondingMolecular ConformationProtein Conformation, beta-StrandHydrogenIsotopesH-bond cooperativityH/D exchangeNMRβ-sheet

Identifiers

PMID36499147

DOI10.3390/ijms232314821

PMCPMC9740688

OpenAlexW4310375515

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.