Evidence map›Paper›PMID 36499094›Full record

ArticleInternational journal of molecular sciences2022

Te-Kai Sun, Wen-Chin Huang, Yu-Wen Sun, Jeng-Shyan Deng, Liang-Hsuan Chien, Ya-Ni Chou, Wen-Ping Jiang, Jaung-Geng Lin, Guan-Jhong Huang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Cisplatin-Induced Nephrotoxicity Attenuation byInternational journal of molecular sciences · 2026
    Article
  2. Bioactive Compounds ofInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Molecular Interactions and Mechanisms of COVID-19 Inhibition 2.0.International journal of molecular sciences · 2024
    Article
  7. Article
  8. International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Te-Kai SunSchool of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan.
Wen-Chin HuangGraduate Institute of Biomedical Sciences, School of Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0003-2342-9099
Yu-Wen SunDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Jeng-Shyan DengDepartment of Food Nutrition and Healthy Biotechnology, Asia University, Taichung 413, Taiwan.
Liang-Hsuan ChienDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-8737-3410
Ya-Ni ChouDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Wen-Ping JiangDepartment of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan.
Jaung-Geng LinSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Guan-Jhong HuangDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-9822-3485
China Medical University · TWAsia University · TWChia Nan University of Pharmacy and Science · TW

Funding

Asia university ASIA-110-CMUH-02
6 · The paper itself

Abstract

The current global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of COVID-19 has infected hundreds of millions of people, killed millions, and continues to pose a threat. It has become one of the largest epidemics in human history, causing enormous damage to people's lives and economies in the whole world. However, there are still many uncertainties and continued attention to the impact of SARS-CoV-2 on human health. The entry of SARS-CoV-2 into host cells is facilitated by the binding of the spike protein on the virus surface to the cell surface receptor angiotensin-converting enzyme 2 (ACE2). Furthermore, transmembrane protease serine 2 (TMPRSS2) is a host surface protease that cleaves and proteolytically activates its S protein, which is necessary for viral infection. Thus, SARS-CoV-2 uses the ACE2 receptor for cell entry and initiates the S protein using the protease TMPRSS2.

Indexed as

Angiotensin-Converting Enzyme 2Biological ProductsCOVID-19SchizophyllumSerine EndopeptidasesAdenosineHumansSARS-CoV-2ACE2 protein, humanAdenosineAngiotensin-Converting Enzyme 2Biological ProductsSerine EndopeptidasesTMPRSS2 protein, humanACE2adenosineSARS-CoV-2Schizophyllum communeTMPRSS2

Identifiers

PMID36499094
PMCPMC9740160
OpenAlexW4310177881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.