Evidence map›Paper›PMID 36499056›Full record

ArticleInternational journal of molecular sciences2022

Comparative Efficiency of Gene-Activated Matrices Based on Chitosan Hydrogel and PRP Impregnated with

Irina Alekseevna Nedorubova, Tatiana Borisovna Bukharova, Viktoria Olegovna Mokrousova, Maria Aleksandrovna Khvorostina, Andrey Vyacheslavovich Vasilyev, Andrey Anatolevich Nedorubov, Timofei Evgenevich Grigoriev, Yuriy Dmitrievich Zagoskin, Sergei Nicolaevich Chvalun, Sergey Ivanovich Kutsev and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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  10. Special Issue "Stem Cell Biology & Regenerative Medicine".International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Irina Alekseevna NedorubovaResearch Centre for Medical Genetics, 115478 Moscow, Russia.ORCID 0000-0001-8472-7116
Tatiana Borisovna BukharovaResearch Centre for Medical Genetics, 115478 Moscow, Russia.ORCID 0000-0003-0481-256X
Viktoria Olegovna MokrousovaResearch Centre for Medical Genetics, 115478 Moscow, Russia.
Maria Aleksandrovna KhvorostinaResearch Centre for Medical Genetics, 115478 Moscow, Russia.
Andrey Vyacheslavovich VasilyevResearch Centre for Medical Genetics, 115478 Moscow, Russia.ORCID 0000-0002-7169-2724
Andrey Anatolevich NedorubovInstitute of Translational Medicine and Biotechnology, Sechenov University, 119991 Moscow, Russia.ORCID 0000-0002-5915-7999
Timofei Evgenevich GrigorievNRC "Kurchatov Institute", 123182 Moscow, Russia.
Yuriy Dmitrievich ZagoskinNRC "Kurchatov Institute", 123182 Moscow, Russia.
Sergei Nicolaevich ChvalunNRC "Kurchatov Institute", 123182 Moscow, Russia.
Sergey Ivanovich KutsevResearch Centre for Medical Genetics, 115478 Moscow, Russia.
Dmitry Vadimovich GoldshteinResearch Centre for Medical Genetics, 115478 Moscow, Russia.
Research Centre for Medical Genetics · RUKurchatov Institute · RURussian Academy of Sciences · RUSechenov University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation AAAA-A19-119011890097-8
6 · The paper itself

Abstract

Gene therapy is one of the most promising approaches in regenerative medicine. Gene-activated matrices provide stable gene expression and the production of osteogenic proteins in situ to stimulate osteogenesis and bone repair. In this study, we developed new gene-activated matrices based on polylactide granules (PLA) impregnated with

Indexed as

ChitosanMesenchymal Stem CellsAnimalsBone Morphogenetic Protein 2Bone RegenerationCell DifferentiationFibrinHydrogelsOsteogenesisRatsBone Morphogenetic Protein 2ChitosanFibrinHydrogelsbone regenerationchitosangene-activated matricesplasmid DNAplatelet rich plasmapolylactide granules

Identifiers

PMID36499056
PMCPMC9735524
OpenAlexW4310249112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.