Evidence map›Paper›PMID 36499055›Full record

ArticleInternational journal of molecular sciences2022

Cerebral Blood Flow in Predator Stress-Resilient and -Susceptible Rats and Mechanisms of Resilience.

Marina V Kondashevskaya, H Fred Downey, Vadim E Tseilikman, Valery V Alexandrin, Kseniya A Artem'yeva, Valentina V Aleksankina, Olga B Tseilikman, Anton A Pashkov, Anna V Goryacheva, Irina S Ivleva and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Marina V KondashevskayaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow 117418, Russia.ORCID 0000-0002-8096-5974
H Fred DowneySchool of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.ORCID 0000-0002-7280-1021
Vadim E TseilikmanSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.
Valery V AlexandrinInstitute of General Pathology and Pathophysiology, Moscow 125315, Russia.ORCID 0000-0003-4625-6522
Kseniya A Artem'yevaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow 117418, Russia.ORCID 0000-0002-1014-752X
Valentina V AleksankinaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow 117418, Russia.
Olga B TseilikmanSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.
Anton A PashkovSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.
Anna V GoryachevaInstitute of General Pathology and Pathophysiology, Moscow 125315, Russia.
Irina S IvlevaPavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg 197376, Russia.
Marina N KarpenkoPavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg 197376, Russia.
Vladislav A ShatilovSchool of Basic Medicine, Chelyabinsk State University, Chelyabinsk 117418, Russia.
Eugenia B ManukhinaSchool of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.ORCID 0000-0002-8102-173X
South Ural State University · RUResearch Institute of Human Morphology · RUInstitute of Experimental Medicine · RUResearch Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUChelyabinsk State University · RU

Funding

Program for strategic academic leadership Priority-2030
6 · The paper itself

Abstract

Stress-induced conditions are associated with impaired cerebral blood flow (CBF) and increased risk of dementia and stroke. However, these conditions do not develop in resilient humans and animals. Here the effects of predator stress (PS, cat urine scent, ten days) on CBF and mechanisms of CBF regulation were compared in PS-susceptible (PSs) and PS-resilient (PSr) rats. Fourteen days post-stress, the rats were segregated into PSs and PSr groups based on a behavior-related anxiety index (AI). CBF and its endothelium-dependent changes were measured in the parietal cortex by laser Doppler flowmetry. The major findings are: (1) PS susceptibility was associated with reduced basal CBF and endothelial dysfunction. In PSr rats, the basal CBF was higher, and endothelial dysfunction was attenuated. (2) CBF was inversely correlated with the AI of PS-exposed rats. (3) Endothelial dysfunction was associated with a decrease in eNOS mRNA in PSs rats compared to the PSr and control rats. (4) Brain dopamine was reduced in PSs rats and increased in PSr rats. (5) Plasma corticosterone of PSs was reduced compared to PSr and control rats. (6) A hypercoagulation state was present in PSs rats but not in PSr rats. Thus, potential stress resilience mechanisms that are protective for CBF were identified.

Indexed as

BrainCerebrovascular CirculationAnimalsCorticosteroneDopamineHumansLaser-Doppler FlowmetryRatsCorticosteroneDopaminecerebral blood flowcorticosteronedopamineendothelial dysfunctionhemostasispost-traumatic stress disorderpredator stressresilience

Identifiers

PMID36499055
PMCPMC9738343
OpenAlexW4310249224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.