Evidence map›Paper›PMID 36498939›Full record

ArticleInternational journal of molecular sciences2022

In Vivo Sustained Release of the Retrograde Transport Inhibitor Retro-2.1 Formulated in a Thermosensitive Hydrogel.

Robin Vinck, Laetitia Anvi Nguyen, Mathilde Munier, Lucie Caramelle, Diana Karpman, Julien Barbier, Alain Pruvost, Jean-Christophe Cintrat, Daniel Gillet

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Robin VinckSIMoS, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, INRAE, 91191 Gif-sur-Yvette, France.ORCID 0000-0002-2730-0121
Laetitia Anvi NguyenSPI, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, INRAE, 91191 Gif-sur-Yvette, France.
Mathilde MunierSCBM, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, INRAE, 91191 Gif-sur-Yvette, France.
Lucie CaramelleSIMoS, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, INRAE, 91191 Gif-sur-Yvette, France.
Diana KarpmanDepartment of Pediatrics, Clinical Sciences Lund, Lund University, 22242 Lund, Sweden.ORCID 0000-0001-7220-7658
Julien BarbierSIMoS, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, INRAE, 91191 Gif-sur-Yvette, France.ORCID 0000-0003-2187-4973
Alain PruvostSPI, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, INRAE, 91191 Gif-sur-Yvette, France.ORCID 0000-0002-7781-7735
Jean-Christophe CintratSCBM, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, INRAE, 91191 Gif-sur-Yvette, France.ORCID 0000-0001-5758-8077
Daniel GilletSIMoS, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris-Saclay, CEA, INRAE, 91191 Gif-sur-Yvette, France.ORCID 0000-0003-0477-3599

Funding

Agence Nationale de la Recherche ANR-14-CE16-0004Agence Nationale de la Recherche ANR-20-CE18-0016-01Labex Action ANR-10-LABX-33Swedish Research Council K2015-99X-22877-01-6
6 · The paper itself

Abstract

A recently developed inhibitor of retrograde transport, namely Retro-2.1, proved to be a potent and broad-spectrum lead in vitro against intracellular pathogens, such as toxins, parasites, intracellular bacteria and viruses. To circumvent its low aqueous solubility, a formulation in poly(ethylene glycol)-

Indexed as

HydrogelsNanoparticlesAnimalsDelayed-Action PreparationsMicePolyethylene GlycolsPolymersTemperatureDelayed-Action PreparationsHydrogelsPolyethylene GlycolsPolymersbroad spectrumformulationmetabolismpharmacokineticRetro-2.1retrograde transport inhibitorthermosensitive hydrogel

Identifiers

PMID36498939
PMCPMC9735573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.