Evidence map›Paper›PMID 36498929›Full record

ArticleInternational journal of molecular sciences2022

An Exploratory Study Provides Insights into MMP9 and Aβ Levels in the Vitreous and Blood across Different Ages and in a Subset of AMD Patients.

Savannah A Lynn, Flavie Soubigou, Jennifer M Dewing, Amanda Smith, Joanna Ballingall, Thea Sass, Isabela Nica, Catrin Watkins, Bhaskar Gupta, Hussein Almuhtaseb and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Savannah A LynnClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK.
Flavie SoubigouClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK.
Jennifer M DewingClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK.
Amanda SmithEye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Joanna BallingallEye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Thea SassEye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Isabela NicaEye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Catrin WatkinsEye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Bhaskar GuptaEye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0000-0002-2122-3559
Hussein AlmuhtasebEye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0000-0002-9137-0618
Stephen C LashEye Unit, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Ho Ming YuenPrimary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, MP 801, Tremona Road, Southampton SO16 6YD, UK.
Angela CreeClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK.
Tracey A NewmanClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK.ORCID 0000-0002-3727-9258
Andrew J LoteryClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK.ORCID 0000-0001-5541-4305
J Arjuna RatnayakaClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, MP806, Tremona Road, Southampton SO16 6YD, UK.ORCID 0000-0002-1027-6938
University Hospital Southampton NHS Foundation Trust · GBUniversity of Southampton · GB

Funding

Alzheimer's Research UK South Coast Network Pump prime awards to S.A.L and J.M.DFight for Sight Fight for Sight and Alzheimer's Research UK (Ref: 24AZ172)Gift of Sight Appeal Grant SupportNational Centre for the Replacement Refinement and Reduction of Animals in Research NC/L001152/1 and NC/T002336/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/L001152/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/T002336/1Retina UK GR590
6 · The paper itself

Abstract

Matrix metalloproteinase-9 (MMP9) and total amyloid-beta (Aβ) are prospective biomarkers of ocular ageing and retinopathy. These were quantified by ELISA in the vitreous and blood from controls (

Indexed as

Macular DegenerationMatrix Metalloproteinase 9Amyloid beta-PeptidesBiomarkersEnzyme-Linked Immunosorbent AssayHumansAmyloid beta-PeptidesBiomarkersMatrix Metalloproteinase 9MMP9 protein, humanage-related macular degeneration (AMD)amyloid beta (Aβ)biomarkerslifecourselifestylemean arterial pressureMMP9smoking

Identifiers

PMID36498929
PMCPMC9736887
OpenAlexW4310007014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.