Evidence map›Paper›PMID 36498926›Full record

ArticleInternational journal of molecular sciences2022

Inhibition of the MAPK/c-Jun-EGR1 Pathway Decreases Photoreceptor Cell Death in the

Yujie Dong, Wenrong Xu, Yan Li, Chunling Wei, Yunzhang Hu, Zhulin Hu, François Paquet-Durand, Kangwei Jiao

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yujie DongYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan University, 176 Qingnian, Kunming 650021, China.ORCID 0000-0003-3246-5913
Wenrong XuYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan University, 176 Qingnian, Kunming 650021, China.
Yan LiYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan University, 176 Qingnian, Kunming 650021, China.
Chunling WeiYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan University, 176 Qingnian, Kunming 650021, China.
Yunzhang HuChinese Academy of Medical Sciences, Jiaoling, Kunming 650031, China.
Zhulin HuYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan University, 176 Qingnian, Kunming 650021, China.
François Paquet-DurandInstitute for Ophthalmic Research, Eberhard-Karls-Universität Tübingen, 72076 Tübingen, Germany.ORCID 0000-0001-7355-5742
Kangwei JiaoYunnan Eye Institute & Key Laboratory of Yunnan Province, Yunnan Eye Disease Clinical Medical Center, Affiliated Hospital of Yunnan University, Yunnan University, 176 Qingnian, Kunming 650021, China.ORCID 0000-0003-3202-5993
Yunnan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of Tübingen · DE

Funding

National Natural Science Foundation of China 81960180the German Research Council DFG: PA1751/10-1the Yunnan Applied Basic Research Projects 2019FB093Yunnan Eye Disease Clinical Medical Center ZX2019-02-01
6 · The paper itself

Abstract

Retinitis pigmentosa (RP) is a group of inherited retinal dystrophies that typically results in photoreceptor cell death and vision loss. Here, we explored the effect of early growth response-1 (EGR1) expression on photoreceptor cell death in

Indexed as

Retinal DegenerationRetinitis PigmentosaAnimalsCell DeathDisease Models, AnimalEarly Growth Response Protein 1MicePhotoreceptor Cells, VertebrateEarly Growth Response Protein 1Egr1 protein, mouseMAPK/c-Jun-EGR1PDE6 genephotoreceptor cellspoly (ADP-ribose) polymerase-1retinitis pigmentosa

Identifiers

PMID36498926
PMCPMC9740268
OpenAlexW4309964518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.