Evidence map›Paper›PMID 36498916›Full record

ArticleInternational journal of molecular sciences2022

19S Proteasome Subunits as Oncogenes and Prognostic Biomarkers in FLT3-Mutated Acute Myeloid Leukemia (AML).

Joshua J Lara, Alfonso E Bencomo-Alvarez, Mayra A Gonzalez, Idaly M Olivas, James E Young, Jose L Lopez, Vanessa V Velazquez, Steven Glovier, Mehrshad Keivan, Andres J Rubio and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Joshua J LaraPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Alfonso E Bencomo-AlvarezCenter of Emphasis in Cancer, Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.ORCID 0000-0002-1771-8532
Mayra A GonzalezCenter of Emphasis in Cancer, Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Idaly M OlivasL. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
James E YoungL. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Jose L LopezPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Vanessa V VelazquezPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Steven GlovierL. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Mehrshad KeivanL. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Andres J RubioPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.ORCID 0000-0002-9077-3554
Sara K DangPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Jonathan P SoleckiL. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Jesse C AllenPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.ORCID 0000-0002-4375-0712
Desiree N TapiaPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Boranai TychhonPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.ORCID 0000-0003-4067-626X
Gonzalo E AstudilloPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Connor JordanL. Frederick Francis Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.
Darshan S ChandrashekarDepartment of Pathology-Molecular & Cellular, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Anna M EiringPaul L. Foster School of Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX 79905, USA.ORCID 0000-0001-6533-9150
Texas Tech University · USUniversity of Alabama at Birmingham · US

Funding

G0S2 in Chronic Myeloid Leukemia Disease Progression and Imatinib ResistanceK22CA216008 · NCI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI EIRING, ANNA MARIE · 2018 to 2021
$704k
American Society of Hematology N/AElsa U. Pardee Foundation N/ANCI NIH HHS K22 CA216008
6 · The paper itself

Abstract

26S proteasome non-ATPase subunits 1 (PSMD1) and 3 (PSMD3) were recently identified as prognostic biomarkers and potential therapeutic targets in chronic myeloid leukemia (CML) and multiple solid tumors. In the present study, we analyzed the expression of 19S proteasome subunits in acute myeloid leukemia (AML) patients with mutations in the FMS-like tyrosine kinase 3 (

Indexed as

fms-Like Tyrosine Kinase 3Leukemia, Myeloid, AcuteHumansMutationOncogenesPrognosisProteasome Endopeptidase ComplexFLT3 protein, humanfms-Like Tyrosine Kinase 3Proteasome Endopeptidase Complexacute myeloid leukemia (AML)FMS-like tyrosine kinase 3 (FLT3)proteasome 26S subunit non-ATPase 3 (PSMD3)proteasome inhibition

Identifiers

PMID36498916
PMCPMC9740165
OpenAlexW4309835920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.