Evidence map›Paper›PMID 36498894›Full record

ReviewInternational journal of molecular sciences2022

Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β.

Isaac Jardin, Alejandro Berna-Erro, Joel Nieto-Felipe, Alvaro Macias, Jose Sanchez-Collado, Jose J Lopez, Gines M Salido, Juan A Rosado

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Physiological functions of calcium signaling via Orai1 in cancer.The journal of physiological sciences : JPS · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Isaac JardinDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.ORCID 0000-0003-4575-8264
Alejandro Berna-ErroDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.
Joel Nieto-FelipeDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.ORCID 0000-0001-6342-3893
Alvaro MaciasDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.
Jose Sanchez-ColladoDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.
Jose J LopezDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.ORCID 0000-0002-5234-1478
Gines M SalidoDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.ORCID 0000-0002-8687-2445
Juan A RosadoDepartment of Physiology (Cellular Physiology Research Group), Institute of Molecular Pathology Biomarkers (IMPB), University of Extremadura, 10003 Caceres, Spain.ORCID 0000-0002-9749-2325
Universidad de Extremadura · ES

Funding

Agencia Estatal de Investigación/AEI/10.13039/501100011033 PID2019-104084GB-C21Consejería de Educación y Empleo GR21008Consejería de Educación y Empleo IB20007Consejería de Educación y Empleo TA18011
6 · The paper itself

Abstract

Orai1, the first identified member of the Orai protein family, is ubiquitously expressed in the animal kingdom. Orai1 was initially characterized as the channel responsible for the store-operated calcium entry (SOCE), a major mechanism that allows cytosolic calcium concentration increments upon receptor-mediated IP

Indexed as

CalciumCalcium ChannelsAnimalsCalcium SignalingIon TransportORAI1 ProteinStromal Interaction Molecule 1TRPC Cation ChannelsCalciumCalcium ChannelsORAI1 ProteinStromal Interaction Molecule 1TRPC Cation ChannelsAC8CRACNFATOrai1αOrai1βSTIM1TRPC1

Identifiers

PMID36498894
PMCPMC9735889
OpenAlexW4309712946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.