Evidence map›Paper›PMID 36498857›Full record

ArticleInternational journal of molecular sciences2022

Pharmacophore Synergism in Diverse Scaffold Clinches in Aurora Kinase B.

Vijay H Masand, Sami A Al-Hussain, Mithilesh M Rathore, Sumer D Thakur, Siddhartha Akasapu, Abdul Samad, Aamal A Al-Mutairi, Magdi E A Zaki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Vijay H MasandDepartment of Chemistry, Vidya Bharati Mahavidyalaya, Amravati 444602, Maharashtra, India.
Sami A Al-HussainDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia.
Mithilesh M RathoreDepartment of Chemistry, Vidya Bharati Mahavidyalaya, Amravati 444602, Maharashtra, India.
Sumer D ThakurDepartment of Chemistry, RDIK and NKD College, Badnera, Amravati 444701, Maharashtra, India.
Siddhartha AkasapuCuria Global, Springfield, MO 65807, USA.
Abdul SamadDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tishk International University, Erbil 44001, Iraq.ORCID 0000-0001-6518-6131
Aamal A Al-MutairiDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia.ORCID 0000-0002-6864-9557
Magdi E A ZakiDepartment of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia.ORCID 0000-0002-5643-9202
Imam Mohammad ibn Saud Islamic University · SASant Gadge Baba Amravati University · INTishk International University · IQ

Funding

Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia research group number RG-21-09-77
6 · The paper itself

Abstract

Aurora kinase B (AKB) is a crucial signaling kinase with an important role in cell division. Therefore, inhibition of AKB is an attractive approach to the treatment of cancer. In the present work, extensive quantitative structure-activity relationships (QSAR) analysis has been performed using a set of 561 structurally diverse aurora kinase B inhibitors. The Organization for Economic Cooperation and Development (OECD) guidelines were used to develop a QSAR model that has high statistical performance (R

Indexed as

PharmacophoreQuantitative Structure-Activity RelationshipAurora Kinase BMolecular Docking SimulationAurora Kinase Baurora kinase Bpharmacophore modelingQSAR

Identifiers

PMID36498857
PMCPMC9739353
OpenAlexW4309570012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.