ArticleInternational journal of molecular sciences2022
Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling.
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Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Sphingolipid Signaling in Vascular Smooth Muscle Cells during Development and Diseases.JMA journal · 2026Review
- Targeting the Hippo pathway in pulmonary arterial hypertension: emerging pharmacological strategies.Journal of hypertension · 2026Review
- Activation of PBK by Gal-3 contributes to pulmonary artery hypertension by promoting PRC1 activation.Respiratory research · 2026Article
- Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization.Nature cardiovascular research · 2026Article
- Roles of Lipid Metabolism in Pulmonary Hypertension: Friend or Foe?Biomolecules · 2025Review
- Pulmonary Hypertension Promotes Neuroinflammation and Neurodegeneration.bioRxiv : the preprint server for biology · 2025Article
- Oxidative Stress and Inflammation in Hypoxemic Respiratory Diseases and Their Comorbidities: Molecular Insights and Diagnostic Advances in Chronic Obstructive Pulmonary Disease and Sleep Apnea.Antioxidants (Basel, Switzerland) · 2025Review
- The mitochondrial unfolded protein response and metabolic reprogramming promote PASMC proliferation in response to sphingosine kinase-1/sphingosine-1-phosphate signaling.bioRxiv : the preprint server for biology · 2025Article
- Sphingosine kinase 1 inhibition aggravates vascular smooth muscle cell calcification.Pflugers Archiv : European journal of physiology · 2025Article
- YAP/TAZ as mechanobiological signaling pathway in cardiovascular physiological regulation and pathogenesis.Mechanobiology in medicine · 2024Article
- Review
- Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension.Journal of translational medicine · 2023Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 2 countries.
Jiwang ChenDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Angelia LockettDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Shuangping ZhaoDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Long Shuang HuangDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-2477-5583
Yifan WangDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Weiwen WuDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Ming TangDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Shahzaib HaiderDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Daniela Velez RendonDepartment of Bioengineering, University of Illinois at Chicago, Chicago, IL 60612, USA.
Raheel KhanDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-6470-0327
Bing LiuDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Nicholas FelesenaDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Justin R SysolDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Daniela Valdez-JassoDepartment of Bioengineering, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-7121-2121
Haiyang TangState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510030, China.ORCID 0000-0001-9537-2891
Yang BaiDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-4420-4553
Viswanathan NatarajanDepartment of Medicine, Section of Pulmonary, Critical Care Medicine, Sleep and Allergy, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-5132-8212
Roberto F MachadoDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
University of Illinois Chicago · USIndiana University School of MedicineFirst Affiliated Hospital of Guangzhou Medical University · CNUniversity of California San Diego · US
Funding
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2MStructure-Function Analysis of nmMLCK in EC Barrier ResponsesP01HL126609 · NHLBI · UNIVERSITY OF FLORIDA · PI Carol C Gregorio · 2016 to 2026
$24.4MTraining In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1MVascular Targeting Genomic & Genetic Strategies for Acute Chest SyndromeR01HL111656 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Roberto F. Machado · 2013 to 2026
$7.9MRole of Sphingolipid Pathways in the Pathobiology of PAHR01HL127342 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MACHADO, ROBERTO F., NATARAJAN, VISWANATHAN · 2016 to 2023
$4.5MUCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3MNAD-dependent Signaling and Pulmonary Vascular Remodeling in PAHR01HL158108 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MACHADO, ROBERTO F. · 2022 to 2025
$2.9MMultiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial HypertensionR01HL155945 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VALDEZ-JASSO, DANIELA · 2021 to 2025
$1.9MRegulation of UPRmt activation in the development of pulmonary vascular remodeling in PAHK01HL164874 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LOCKETT, ANGELIA DENISE · 2022 to 2024
$336kNCATS NIH HHS UL1 TR002529NHLBI NIH HHS K01 HL164874NHLBI NIH HHS P01 HL126609NHLBI NIH HHS R01 HL111656NHLBI NIH HHS R01 HL127342NHLBI NIH HHS R01 HL155945NHLBI NIH HHS R01 HL158108NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444
Abstract
Sphingosine kinase 1 (SPHK1) and the sphingosine-1-phosphate (S1P) signaling pathway have been shown to play a role in pulmonary arterial hypertension (PAH). S1P is an important stimulus for pulmonary artery smooth muscle cell (PASMC) proliferation and pulmonary vascular remodeling. We aimed to examine the specific roles of SPHK1 in PASMCs during pulmonary hypertension (PH) progression. We generated smooth muscle cell-specific,
Indexed as
Hypertension, PulmonaryPhosphotransferases (Alcohol Group Acceptor)YAP-Signaling ProteinsAnimalsCell ProliferationCells, CulturedHypoxiaMiceMyocytes, Smooth MusclePulmonary ArteryRatsSignal TransductionSphingosineSphingosine KinaseVascular RemodelingPhosphotransferases (Alcohol Group Acceptor)SphingosineSphingosine KinaseSphk1 protein, mouseYap1 protein, mouseYAP-Signaling Proteinsproliferationpulmonary artery smooth muscle cellpulmonary hypertensionS1Psphingosine kinase 1verteporfinYAP1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.