Evidence map›Paper›PMID 36498839›Full record

ArticleInternational journal of molecular sciences2022

Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration.

Yu-Hao Lin, Yao-Hsiang Shih, Ye Vone Yap, Yen-Wei Chen, Hsiang-Lin Kuo, Tsung-Yun Liu, Li-Jin Hsu, Yu-Min Kuo, Nan-Shan Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Zfra Overrides WWOX in Suppressing the Progression of Neurodegeneration.International journal of molecular sciences · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yu-Hao LinInstitute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Yao-Hsiang ShihDepartment of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0001-9145-7492
Ye Vone YapInstitute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Yen-Wei ChenInstitute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Hsiang-Lin KuoInstitute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Tsung-Yun LiuInstitute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Li-Jin HsuDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Yu-Min KuoDepartment of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0003-4867-2482
Nan-Shan ChangInstitute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0002-6889-8756
National Cheng Kung University · TWKaohsiung Medical University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 108-2320-B-006-020Ministry of Science and Technology, Taiwan MOST 109-2320-B-006-058Ministry of Science and Technology, Taiwan MOST 110-2320-B-006-056National Health Research Institute, Taiwan NHRI-EX107-10734NIUnited States Department of Defense W81XWH-08-1-0682
6 · The paper itself

Abstract

When WWOX is downregulated in middle age, aggregation of a protein cascade, including TRAPPC6AΔ (TPC6AΔ), TIAF1, and SH3GLB2, may start to occur, and the event lasts more than 30 years, which results in amyloid precursor protein (APP) degradation, amyloid beta (Aβ) generation, and neurodegeneration, as shown in Alzheimer's disease (AD). Here, by treating neuroblastoma SK-N-SH cells with neurotoxin MPP+, upregulation and aggregation of TPC6AΔ, along with aggregation of TIAF1, SH3GLB2, Aβ, and tau, occurred. MPP+ is an inducer of Parkinson's disease (PD), suggesting that TPC6AΔ is a common initiator for AD and PD pathogenesis. Zfra, a 31-amino-acid zinc finger-like WWOX-binding protein, is known to restore memory deficits in 9-month-old triple-transgenic (3xTg) mice by blocking the aggregation of TPC6AΔ, SH3GLB2, tau, and amyloid β, as well as inflammatory NF-κB activation. The Zfra4-10 peptide exerted a strong potency in preventing memory loss during the aging of 3-month-old 3xTg mice up to 9 months, as determined by a novel object recognition task (ORT) and Morris water maize analysis. Compared to age-matched wild type mice, 11-month-old

Indexed as

Adaptor Proteins, Signal TransducingAlzheimer DiseaseAmyloid beta-PeptidesParkinson DiseaseAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalMemory DisordersMiceMice, TransgenicSignal Transductiontau ProteinsUbiquitin-Protein Ligase ComplexesAdaptor Proteins, Signal TransducingAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAppbp2 protein, mouseSh3glb2 protein, mousetau ProteinsUbiquitin-Protein Ligase ComplexesAlzheimer’s diseasep53SH3GLB2TIAF1TRAPPC6ATRAPPC6AΔtumor suppressorWWOX

Identifiers

PMID36498839
PMCPMC9739312
OpenAlexW4309570499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.