Evidence map›Paper›PMID 36498813›Full record

ReviewJournal of clinical medicine2022

Long-Term Effects of Breast Cancer Therapy and Care: Calm after the Storm?

Chiara Tommasi, Rita Balsano, Matilde Corianò, Benedetta Pellegrino, Giorgio Saba, Fabio Bardanzellu, Nerina Denaro, Matteo Ramundo, Ilaria Toma, Alessandro Fusaro and 5 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07107594 (Multimodal Intervention During Neoadjuvant Chemotherapy in Patients With Early-breast Cancer as a Strategy to Improve Treatment Response), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07107594 narecruitingnot on this mapstarted 2025, after this paper: background citation

Multimodal Intervention During Neoadjuvant Chemotherapy in Patients With Early-breast Cancer as a Strategy to Improve Treatment Response: DIANA Trial (Multimodal Prehabilitation: DIet, ANxiety Control Psychotherapy, Physical Activity)

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2025 to 2028Enrolled214ConditionsBreast Cancer Early Stage Breast Cancer (Stage 1-3), PrehabilitationArmsMultimodal prehabilitation
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Antitumor Effects ofMolecules (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Article
  7. Factors affecting shoulder joint range of motion after breast cancer surgery: a retrospective cohort study in Japan.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Targeting triple-negative breast cancer: apoptotic and antitumor effects of Artemisia sieberi Besser extracts.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Article
  15. Article
  16. Exploring the Anticancer Potential ofCurrent issues in molecular biology · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chiara TommasiMedical Oncology and Breast Unit, University Hospital of Parma, 43126 Parma, Italy.ORCID 0000-0002-9230-9288
Rita BalsanoMedical Oncology and Breast Unit, University Hospital of Parma, 43126 Parma, Italy.ORCID 0000-0003-4368-6973
Matilde CorianòMedical Oncology and Breast Unit, University Hospital of Parma, 43126 Parma, Italy.
Benedetta PellegrinoMedical Oncology and Breast Unit, University Hospital of Parma, 43126 Parma, Italy.
Giorgio SabaMedical Oncology Department, University of Cagliari, 09042 Cagliari, Italy.
Fabio BardanzelluMedical Oncology Department, University of Cagliari, 09042 Cagliari, Italy.
Nerina DenaroMedical Oncology, Fondazione Ca' Grande Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0002-8605-4290
Matteo RamundoUnità Operativa Complessa di Oncologia, Azienda Ospedaliera Cardinale G. Panico, 73039 Tricase, Italy.
Ilaria TomaUnità Operativa Complessa di Oncologia, Azienda Ospedaliera Cardinale G. Panico, 73039 Tricase, Italy.
Alessandro FusaroLILT Valle d'Aosta, 11100 Aosta, Italy.
Serafina MartellaMedical Oncology, University Hospital Policlinico San Marco, 95123 Catania, Italy.
Marco Maria AielloMedical Oncology, University Hospital Policlinico San Marco, 95123 Catania, Italy.
Mario ScartozziMedical Oncology Department, University of Cagliari, 09042 Cagliari, Italy.ORCID 0000-0001-5977-5546
Antonino MusolinoMedical Oncology and Breast Unit, University Hospital of Parma, 43126 Parma, Italy.ORCID 0000-0002-7979-6261
Cinzia SolinasMedical Oncology Department, University of Cagliari, 09042 Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is still a lethal disease and the leading cause of death in women, undermining patients' survival and quality of life. Modern techniques of surgery and radiotherapy allow for the obtaining of good results in terms of survival, however they cause long-term side effects that persist over time, such as lymphedema and neuropathy. Similarly, the advent of new therapies such as endocrine therapy revolutionized breast cancer outcomes, but side effects are still present even in years of follow-up after cure. Besides the side effects of medical and surgical therapy, breast cancer is a real disruption in patients' lives considering quality of life-related aspects such as the distortion of body image, the psychological consequences of the diagnosis, and the impact on family dynamics. Therefore, the doctor-patient relationship is central to providing the best support both during treatment and afterwards. The aim of this review is to summarize the consequences of medical and surgical treatment on breast cancer patients and to emphasize the importance of early prevention of side effects to improve patients' quality of life.

Indexed as

breast cancerbreast cancer survivorspsychological impactquality of lifeside effectstoxicity

Identifiers

PMID36498813
PMCPMC9738151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.