ArticleJournal of clinical medicine2022
The Triglyceride-Glucose Index Is Associated with Longitudinal Cognitive Decline in a Middle-Aged to Elderly Population: A Cohort Study.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Exploring the Association Between Cognitive Decline and Triglyceride-Glucose Index: A Systematic Review and Meta-Analysis.Brain and behavior · 2024Pooled it
- The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases.Frontiers in neurology · 2024Pooled it
- Association between the triglyceride glucose index and cognitive impairment and dementia: a meta-analysis.Frontiers in aging neuroscience · 2023Pooled it
- Associations of Prediabetes, Diabetes and Glucose-Related Markers With Cognition and Neuroimaging in a 2-Year Multidomain Lifestyle Randomised Controlled Trial.Diabetes/metabolism research and reviews · 2025Trial
- Metabolic dysfunction and insulin resistance across major dementias: A comprehensive narrative review of the TyG index as a predictive marker.Metabolism open · 2026Review
- Association of TyG index and obesity indicators with cognitive function: a cross - sectional study from Chinese health check-up centers.BMC endocrine disorders · 2026Article
- Association of triglyceride-glucose index (TyG) and a body shape index (ABSI) with cognitive decline and dementia risk.PloS one · 2026Article
- Novel anthropometric indices and cognitive function among iranian older adults: Bushehr Elderly Health (BEH) program.PloS one · 2026Article
- Association between the triglyceride-glucose index and disease severity in non-diabetic Parkinson's disease patients.Frontiers in aging neuroscience · 2026Article
- Understanding Cognitive Decline in Aging: Mechanisms and Mitigation Strategies - A Narrative Review.Clinical interventions in aging · 2025Review
- Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database.Frontiers in physiology · 2025Article
- Association of the triglyceride-glucose index and its related parameters with frailty.Lipids in health and disease · 2024Article
- The central executive network moderates the relationship between posttraumatic stress symptom severity and gastrointestinal related issues.Scientific reports · 2024Article
- Connections between Cognitive Impairment and Atrial Fibrillation in Patients with Diabetes Mellitus Type 2.Biomedicines · 2024Article
- Relationship between triglyceride-glucose index and cognitive function among community-dwelling older adults: a population-based cohort study.Frontiers in endocrinology · 2024Article
- The association between triglyceride-glucose index and cognitive function in nondiabetic elderly: NHANES 2011-2014.Lipids in health and disease · 2023Article
- Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTo examine the effect of the triglyceride-glucose (TyG) index on longitudinal cognitive decline in a healthy middle-aged-to-elderly population.
methodsWe conducted a population-based longitudinal study. A total of 1774 participants without cognitive impairment were enrolled in the 4-year follow-up. They were divided into four groups according to the quartile of the TyG index. Multivariable-adjusted Cox proportional hazard models were performed to examine the association between the TyG index and cognitive decline. Discrimination tests were used to evaluate the incremental predictive value of the TyG index beyond conventional risk factors.
resultsDuring the follow-up, compared with those in the bottom quartile group, participants in the top TyG quartile group presented a 51% increase in the risk of cognitive decline (OR 1.51 (95% CI: 1.06-2.14)). As shown by discrimination tests, adding the TyG index into the conventional model resulted in a slight improvement in predicting the risk of cognitive decline (NRI 16.00% (
conclusionThis study demonstrated that increasing values of the TyG index were positively associated with the risk of cognitive decline. Monitoring the TyG index may help in the early identification of individuals at high risk of cognitive deterioration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.