Evidence map›Paper›PMID 36498636›Full record

ArticleJournal of clinical medicine2022

Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma.

Sebastian Blatt, Maximilian Krüger, Kawe Sagheb, Marie Barth, Peer W Kämmerer, Bilal Al-Nawas, Keyvan Sagheb

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 50 citations in OpenAlex.

  1. Trial
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  8. Surveillance after treatment for head and neck cancer.Current opinion in otolaryngology & head and neck surgery · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. CD44 and Snail1 Expression Predicts Poor Prognosis of Oral Squamous Cell Carcinoma.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sebastian BlattDepartment of Oral- and Maxillofacial Surgery-Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, Germany.
Maximilian KrügerDepartment of Oral- and Maxillofacial Surgery-Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, Germany.
Kawe SaghebDepartment of Prosthetic Dentistry, University Medical Centre, Augustusplatz 2, 55131 Mainz, Germany.ORCID 0000-0002-8249-9962
Marie BarthDepartment of Oral- and Maxillofacial Surgery-Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, Germany.
Peer W KämmererDepartment of Oral- and Maxillofacial Surgery-Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, Germany.ORCID 0000-0002-1671-3764
Bilal Al-NawasDepartment of Oral- and Maxillofacial Surgery-Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, Germany.ORCID 0000-0002-8665-5803
Keyvan SaghebDepartment of Oral- and Maxillofacial Surgery-Plastic Surgery, University Medical Centre, Augustusplatz 2, 55131 Mainz, Germany.ORCID 0000-0002-3866-5900
Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor recurrence in oral squamous cell carcinoma (OSCC) is frequent. However, no consensus about follow-up interval is available. The aim of this study was to analyze the recurrence pattern, detection method and associated parameters for possible risk stratification. Histopathological and epidemiological features were obtained retrospectively and correlated with tumor recurrence and overall survival, distant and lymph node metastases. A total of 760 patients were included, of which 216 patients showed tumor recurrence (mean after 24 ± 26 months). Within the first 12 months, 24% of the recurrences were detected. The primary detection method was clinical examination (n = 123, 57%). Tumor recurrence significantly correlated with advanced histopathological grading (G2/3 vs. G1, p < 0.000) and lymph node metastasis (p = 0.004). Tumor recurrence was frequent. Clinical examination was the primary detection method and manifestation within the first 6−12 months was high. The degree of histopathological grading may be useful for risk stratification.

Indexed as

differentiationoral cancerprognosisrecurrence intervalsquamous cell carcinoma

Identifiers

PMID36498636
PMCPMC9740063
OpenAlexW4310478661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.