Evidence map›Paper›PMID 36498633›Full record

ArticleJournal of clinical medicine2022

Post-Transplant Lymphoproliferative Disorder: A Rare Case of CNS Involvement following Renal Transplant.

Austin Feindt, Montserrat Lara-Velazquez, Ahmad Alkhasawneh, Dinesh Rao, Raafat Makary, Keith Dombrowski, Daryoush Tavanaiepour, Gazanfar Rahmathulla

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Austin FeindtSchool of Medicine, University of South Florida School of Medicine, 12901 Bruce B Downs Blvd., Tampa, FL 33612, USA.
Montserrat Lara-VelazquezDepartment of Neurological Surgery, University of Florida College of Medicine, 653-1 8th St. W, Jacksonville, FL 32209, USA.
Ahmad AlkhasawnehDepartment of Pathology, University of Florida College of Medicine, 8th St. W, Jacksonville, FL 32209, USA.
Dinesh RaoDepartment of Radiology, University of Florida College of Medicine, 8th St. W, Jacksonville, FL 32209, USA.
Raafat MakaryDepartment of Pathology, University of Florida College of Medicine, 8th St. W, Jacksonville, FL 32209, USA.ORCID 0000-0002-8560-035X
Keith DombrowskiDepartment of Neurosurgery and Brain Repair, USF Health, 2 Tampa General Cir, Tampa, FL 33606, USA.
Daryoush TavanaiepourDepartment of Neurological Surgery, University of Florida College of Medicine, 653-1 8th St. W, Jacksonville, FL 32209, USA.
Gazanfar RahmathullaDepartment of Neurological Surgery, University of Florida College of Medicine, 653-1 8th St. W, Jacksonville, FL 32209, USA.
University of Florida · USTampa General Hospital · USUniversity of South Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-transplant lymphoproliferative disorders (PTLD) are rare immunosuppression complications affecting 5% of transplant patients. Isolated central nervous system (CNS)-PTLD without nodal or extra-nodal organ involvement is rarely reported and is difficult to diagnose due to the non-specific clinical manifestations and imaging features overlapping with other common CNS lesions. CASE PRESENTATION: We present a case of a 72-year-old female subjected to a renal transplant 11 years ago with progressively worsening headaches and confusion. Imaging revealed vasogenic edema in the left frontal and bilateral temporal lobes. She was subjected to a craniotomy and excisional biopsy to obtain tissue for diagnostic and therapeutic interventions. Pathology examination showed atypical EBV-positive lymphoplasmacytic infiltrate, consistent with Polymorphic type PTLD.

conclusionsPatients diagnosed with PTLD need to have close monitoring of immunosuppressive medications while in the hospital. Early diagnosis is essential for patient survival with PTLD, as their health can deteriorate fast.

Indexed as

Epstein–Barr virus infectionslymphoproliferative disorderorgan transplantation

Identifiers

PMID36498633
PMCPMC9739215
OpenAlexW4310386987

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.