Evidence map›Paper›PMID 36498578›Full record

ReviewJournal of clinical medicine2022

Neurorehabilitation in Multiple Sclerosis-A Review of Present Approaches and Future Considerations.

Carmen Adella Sîrbu, Dana-Claudia Thompson, Florentina Cristina Plesa, Titus Mihai Vasile, Dragoș Cătălin Jianu, Marian Mitrica, Daniela Anghel, Constantin Stefani

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07098273 (Restoring Manual Dexterity in Multiple Sclerosis), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07098273 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Restoring Manual Dexterity in Multiple Sclerosis: A Feasibility Study Combining Muscle Electrostimulation and Transcranial Magnetic Stimulation To Enhance Neuroplasticity

TypeinterventionalSponsorFondazione Don Carlo Gnocchi ETSRan2025 to 2027Enrolled50ConditionsMultiple SclerosisArmsTMS and FES- based rehabilitation, FES-based rehabilitation
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  13. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Carmen Adella SîrbuDepartment of Neurology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010242 Bucharest, Romania.ORCID 0000-0002-1982-1066
Dana-Claudia ThompsonDepartment of Rehabilitation Medicine, Elias Emergency University Hospital, 011461 Bucharest, Romania.
Florentina Cristina PlesaDepartment of Neurology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010242 Bucharest, Romania.
Titus Mihai VasileDepartment of Neurology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010242 Bucharest, Romania.
Dragoș Cătălin JianuCentre for Cognitive Research in Neuropsychiatric Pathology (Neuropsy-Cog), Department of Neurology, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, 300041 Timișoara, Romania.ORCID 0000-0002-7827-818X
Marian MitricaDepartment of Preclinical Disciplines, Titu Maiorescu University, 031593 Bucharest, Romania.
Daniela AnghelDepartment of Medico-Surgical and Prophylactic Disciplines, Titu Maiorescu University, 031593 Bucharest, Romania.
Constantin StefaniDepartment of Family Medicine and Clinical Base, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010242 Bucharest, Romania.
Titu Maiorescu University · ROCarol Davila University of Medicine and Pharmacy · ROClinical Emergency Hospital Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis is an increasingly prevalent disease, representing the leading cause of non-traumatic neurological disease in Europe and North America. The most common symptoms include gait deficits, balance and coordination impairments, fatigue, spasticity, dysphagia and an overactive bladder. Neurorehabilitation therapeutic approaches aim to alleviate symptoms and improve the quality of life through promoting positive immunological transformations and neuroplasticity. The purpose of this study is to evaluate the current treatments for the most debilitating symptoms in multiple sclerosis, identify areas for future improvement, and provide a reference guide for practitioners in the field. It analyzes the most cited procedures currently in use for the management of a number of symptoms affecting the majority of patients with multiple sclerosis, from different training routines to cognitive rehabilitation and therapies using physical agents, such as electrostimulation, hydrotherapy, cryotherapy and electromagnetic fields. Furthermore, it investigates the quality of evidence for the aforementioned therapies and the different tests applied in practice to assess their utility. Lastly, the study looks at potential future candidates for the treatment and evaluation of patients with multiple sclerosis and the supposed benefits they could bring in clinical settings.

Indexed as

balancedysphagiafatiguegaitmultiple sclerosisneurorehabilitationoveractive bladderrehabilitationspasticity

Identifiers

PMID36498578
PMCPMC9739865
OpenAlexW4310184911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.