Evidence map›Paper›PMID 36498466›Full record

ReviewJournal of clinical medicine2022

Angina in 2022: Current Perspectives.

Roberto Manfredi, Monica Verdoia, Paolo Compagnucci, Alessandro Barbarossa, Giulia Stronati, Michela Casella, Antonio Dello Russo, Federico Guerra, Giuseppe Ciliberti

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Roberto ManfrediCardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti", 60126 Ancona, Italy.
Monica VerdoiaDivision of Cardiology Ospedale degli Infermi, ASL, 13875 Biella, Italy.ORCID 0000-0001-6506-8397
Paolo CompagnucciCardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti", 60126 Ancona, Italy.ORCID 0000-0003-1924-6548
Alessandro BarbarossaCardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti", 60126 Ancona, Italy.
Giulia StronatiCardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti", 60126 Ancona, Italy.ORCID 0000-0001-7095-5732
Michela CasellaCardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti", 60126 Ancona, Italy.
Antonio Dello RussoCardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti", 60126 Ancona, Italy.
Federico GuerraCardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti", 60126 Ancona, Italy.
Giuseppe CilibertiCardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti", 60126 Ancona, Italy.ORCID 0000-0001-8698-5848

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angina is the main symptom of ischemic heart disease; mirroring a mismatch between oxygen supply and demand. Epicardial coronary stenoses are only responsible for nearly half of the patients presenting with angina; whereas in several cases; symptoms may underlie coronary vasomotor disorders; such as microvascular dysfunction or epicardial spasm. Various medications have been proven to improve the prognosis and quality of life; representing the treatment of choice in stable angina and leaving revascularization only in particular coronary anatomies or poorly controlled symptoms despite optimal medical therapy. Antianginal medications aim to reduce the oxygen supply-demand mismatch and are generally effective in improving symptoms; quality of life; effort tolerance and time to ischemia onset and may improve prognosis in selected populations. Since antianginal medications have different mechanisms of action and side effects; their use should be tailored according to patient history and potential drug-drug interactions. Angina with non-obstructed coronary arteries patients should be phenotyped with invasive assessment and treated accordingly. Patients with refractory angina represent a higher-risk population in which some therapeutic options are available to reduce symptoms and improve quality of life; but robust data from large randomized controlled trials are still lacking.

Indexed as

beta-blockerscalcium channel blockerscoronary artery diseasenitratesstable angina

Identifiers

PMID36498466
PMCPMC9737178

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.