Evidence map›Paper›PMID 36498454›Full record

ReviewJournal of clinical medicine2022

Fetal Bradycardia Caused by Monogenic Disorders-A Review of the Literature.

Dominik S Westphal, Michael Hauser, Britt-Maria Beckmann, Cordula M Wolf, Gabriele Hessling, Renate Oberhoffer-Fritz, Annette Wacker-Gussmann

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Pre-natal clues of a genetic tale: how foetal heart rate foretells long QT syndrome.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Dominik S WestphalDepartment of Internal Medicine I, Klinikum Rechts der Isar, School of Medicine and Health, Technical University Munich, 81675 Munich, Germany.ORCID 0000-0003-4870-9863
Michael HauserPraxis für Kinderkardiologie, 80638 Munich, Germany.
Britt-Maria BeckmannInstitute of Legal Medicine, University Hospital Frankfurt, Goethe University, 60596 Frankfurt, Germany.
Cordula M WolfDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80802 Munich, Germany.ORCID 0000-0003-4701-5843
Gabriele HesslingDepartment of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, School of Medicine and Health, Technical University Munich, 80636 Munich, Germany.
Renate Oberhoffer-FritzDepartment of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, School of Medicine and Health, Technical University Munich, 80636 Munich, Germany.ORCID 0000-0002-3166-0488
Annette Wacker-GussmannDepartment of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, School of Medicine and Health, Technical University Munich, 80636 Munich, Germany.
Deutsches Herzzentrum München · DEGerman Centre for Cardiovascular Research · DEGoethe University Frankfurt · DEOrthopädische Praxis · DETUM Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The standard obstetric definition of fetal bradycardia is a sustained fetal heart rate < 110 bpm over at least 10 min. Fetal bradycardia can be the first and only prenatal presentation of a heart disease. We present an overview on different genetic disorders that should be taken into consideration in case of diagnosed fetal bradycardia. Methods: A literature review was conducted using a PubMed- and OMIM-based search for monogenetic disorders causing fetal bradycardia in September 2022. Results: The review on the literature identified nine monogenic diseases that could lead to fetal bradycardia. Four of these disorders can be associated with extracardiac findings. Discussion: Genetic testing should be considered in cases with fetal bradycardia, especially in cases of additional extracardiac findings. Broad sequencing techniques and improved prenatal phenotyping could help to establish a diagnosis in an increasing number of cases.

Indexed as

arrhythmiabradycardiafetalgenetics

Identifiers

PMID36498454
PMCPMC9741304
OpenAlexW4309689213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.