ArticleInternational journal of environmental research and public health2022
The Presence of Ankylosing Spondylitis and the Incidence of Subsequent External Eye Diseases: A Population-Based Cohort Study.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 6 citations in OpenAlex.
- AMPK-mediated modulation of JAK2/STAT3 signaling in asthma: a promising target for controlling airway inflammation and remodeling.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Dry eye disease in axial spondyloarthritis: heterogeneous ocular surface dysfunction involving tear film instability and tear production from the AIDA network registry.Frontiers in medicine · 2026Article
- Article
- Diagnostic Value of Conjunctival Impression Cytology and Nelson Grading in Evaluating Dry Eye Disease in Ankylosing Spondylitis.Medicina (Kaunas, Lithuania) · 2025Article
- Anterior and Posterior Ocular Changes in Patients with Active and Inactive Ankylosing Spondylitis.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Causal relationship between ankylosing spondylitis and ocular inflammatory diseases: a Mendelian randomization study.Frontiers in genetics · 2024Article
- Dry eye disease and spondyloarthritis: expanding the spectrum of systemic inflammatory disorders associated with ocular surface disease. Data from the international AIDA Network Spondyloarthritis Registry.Frontiers in medicine · 2024Article
- Disrupted Neural Regeneration in Dry Eye Secondary to Ankylosing Spondylitis-With a Theoretical Link between Piezo2 Channelopathy and Gateway Reflex, WDR Neurons, and Flare-Ups.International journal of molecular sciences · 2023Article
- The Correlation Between Aortic Stenosis and the Incidence of Subsequent Ocular Surface Diseases.In vivo (Athens, Greece)Article
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7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We aimed to survey the risk of external eye diseases in those with ankylosing spondylitis (AS) via the National Health Insurance Research Database (NHIRD) in Taiwan. We conducted a retrospective cohort study, and subjects diagnosed with AS were selected from the NHIRD. Then, the AS patients were matched 1:1 by propensity-score matching (PSM) to non-AS patients, and a total of 6754 participants were included in the AS and non-AS groups. The main outcomes were regarded as the occurrence of dry eye disease (DED), superficial keratopathy and corneal ulcers. We used Cox proportional hazard regression to yield the adjusted hazard ratios (AHR) with 95% confidence intervals (CI) between the AS and non-AS groups. There were 709 and 408 external eye disease events that occurred in the AS and non-AS groups after a tracking interval of up to 17 years. The incidence of all external eye diseases was significantly higher in the AS group than the non-AS group (AHR: 1.826, 95% CI: 1.616−2.063, p < 0.0001). Additionally, the rates of DED (AHR: 1.973, 95% CI: 1.701−2.290, p < 0.0001) and superficial keratopathy (AHR: 1.593, 95% CI: 1.347−1.883, p < 0.0001) were significantly higher in the AS group than the non-AS group. In the sub-group analyses, the possibility of any external eye disease (p = 0.0030) and DED (p = 0.0386) was decreased in the older age group compared to those in the middle-aged group. In conclusion, AS is significantly correlated to subsequent external eye diseases, mainly the DED and superficial keratopathy.
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