Evidence map›Paper›PMID 36497417›Full record

ArticleCancers2022

Ewing Sarcoma as Secondary Malignant Neoplasm-Epidemiological and Clinical Analysis of an International Trial Registry.

Stefan K Zöllner, Katja L Kauertz, Isabelle Kaiser, Maximilian Kerkhoff, Christiane Schaefer, Madita Tassius, Susanne Jabar, Heribert Jürgens, Ruth Ladenstein, Thomas Kühne and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Extramedullary Relapse ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Stefan K ZöllnerPediatrics III, University Hospital Essen, 45147 Essen, Germany.ORCID 0000-0001-5888-7327
Katja L KauertzPediatrics III, University Hospital Essen, 45147 Essen, Germany.
Isabelle KaiserPediatrics III, University Hospital Essen, 45147 Essen, Germany.
Maximilian KerkhoffPediatrics III, University Hospital Essen, 45147 Essen, Germany.
Christiane SchaeferPediatrics III, University Hospital Essen, 45147 Essen, Germany.
Madita TassiusPediatrics III, University Hospital Essen, 45147 Essen, Germany.
Susanne JabarPediatrics III, University Hospital Essen, 45147 Essen, Germany.
Heribert JürgensPediatric Hematology and Oncology, University Children's Hospital Münster, 48149 Münster, Germany.
Ruth LadensteinSt. Anna Children's Cancer Research Institute and Medical University Vienna, 1090 Vienna, Austria.
Thomas KühneDepartment of Oncology and Haematology, University Children's Hospital Basel, 4056 Basel, Switzerland.ORCID 0000-0002-7387-7028
Lianne M HavemanPrincess Máxima Center for Pediatric Oncology, 3584 Utrecht, The Netherlands.ORCID 0000-0001-8519-8906
Michael PaulussenPediatric Hematology and Oncology, Vestische Children's and Youth Hospital Datteln, University Witten/Herdecke, 45711 Datteln, Germany.
Andreas RanftPediatrics III, University Hospital Essen, 45147 Essen, Germany.ORCID 0000-0003-4424-7569
Uta DirksenPediatrics III, University Hospital Essen, 45147 Essen, Germany.ORCID 0000-0002-5435-7860
Düsseldorf University Hospital · DEPrincess Máxima Center · NLSt Anna Children's Hospital · ATUniversity Children’s Hospital Basel · CHUniversity Hospital Münster · DE

Funding

Deutsche Krebshilfe DKH M43/92/Jü2, 108128, 70-2551 Jü3 and DKH 70112018
6 · The paper itself

Abstract

Ewing sarcoma (EwS) is the second most common bone and soft tissue tumor, affecting primarily adolescents and young adults. Patients with secondary EwS are excluded from risk stratification in several studies and therefore do not benefit from new therapies. More knowledge about patients with EwS as secondary malignant neoplasms (SMN) is needed to identify at-risk patients and adapt follow-up strategies. Epidemiology, clinical characteristics, and survival analyses of EwS as SMN were analyzed in 3844 patients treated in the last three consecutive international EwS trials, EICESS 92, Euro-E.W.I.N.G. 99, and EWING 2008. Forty-two cases of EwS as SMN (approximately 1.1% of all patients) were reported, preceded by a heterogeneous group of malignancies, mainly acute lymphoblastic leukemias (

Indexed as

cancer survivorchildhood cancerEwing sarcomasecondary malignancysecondary malignant neoplasms

Identifiers

PMID36497417
PMCPMC9735743
OpenAlexW4311049777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.