ArticleCancers2022
Management and Prognosis of Cardiac Metastatic Merkel Cell Carcinoma: A Case-Control Study and Literature Review.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Rare Merkel cell carcinoma cardiac involvement: A case of cystic metastasis to the left heart.JAAD case reports · 2026Article
- Intracardiac and Transesophageal Echocardiography-Guided Biopsy of a Large Epicardial Mass.JACC. Case reports · 2026Article
- Multimodality Imaging and Echocardiographic Guidance in Cardiac Mass Diagnosis and Biopsy.JACC. Case reports · 2026Article
- First comprehensive case report of surgical resection of a cardiac Merkel cell carcinoma metastasis.JTCVS techniques · 2025Article
- Pericardial Oligometastasis From Merkel Cell Carcinoma Treated With Stereotactic Ablative Radiotherapy.Cureus · 2025Article
- Merkel Cell Carcinoma: An Update and Review.Cancers · 2023Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
Merkel cell carcinoma (MCC), an aggressive neuroendocrine skin cancer, has a high rate (20%) of distant metastasis. Within a prospective registry of 582 patients with metastatic MCC (mMCC) diagnosed between 2003-2021, we identified 9 (1.5%) patients who developed cardiac metastatic MCC (mMCC). We compared overall survival (OS) between patients with cardiac and non-cardiac metastases in a matched case-control study. Cardiac metastasis was a late event (median 925 days from initial MCC diagnosis). The right heart was predominantly involved (8 of 9; 89%). Among 7 patients treated with immunotherapy, 6 achieved a complete or partial response of the cardiac lesion. Among these 6 responders, 5 received concurrent cardiac radiotherapy (median 20 Gray) with immunotherapy; 4 of 5 did not have local disease progression or recurrence in the treated cardiac lesion. One-year OS was 44%, which was not significantly different from non-cardiac mMCC patients (45%,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.