Evidence map›Paper›PMID 36497290›Full record

ArticleCancers2022

Immune Response and Outcome of High-Risk Neuroblastoma Patients Immunized with Anti-Idiotypic Antibody Ganglidiomab: Results from Compassionate-Use Treatments.

Leah Klingel, Nikolai Siebert, Sascha Troschke-Meurer, Maxi Zumpe, Karoline Ehlert, Stefanie Huber, Hans Loibner, Oliver Mutschlechner, Holger N Lode

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Leah KlingelPediatric Hematology and Oncology, University Medicine Greifswald, 17475 Greifswald, Germany.
Nikolai SiebertPediatric Hematology and Oncology, University Medicine Greifswald, 17475 Greifswald, Germany.
Sascha Troschke-MeurerPediatric Hematology and Oncology, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-6185-462X
Maxi ZumpePediatric Hematology and Oncology, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0003-0297-6739
Karoline EhlertPediatric Hematology and Oncology, University Medicine Greifswald, 17475 Greifswald, Germany.
Stefanie HuberPediatric Hematology and Oncology, University Medicine Greifswald, 17475 Greifswald, Germany.
Hans LoibnerAnyxis Immuno-Oncology GmbH, 1230 Vienna, Austria.
Oliver MutschlechnerAnyxis Immuno-Oncology GmbH, 1230 Vienna, Austria.
Holger N LodePediatric Hematology and Oncology, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-1201-208X
Universitätsmedizin Greifswald · DE

Funding

Deutsche Forschungsgemeinschaft SI 2147Hector Stiftungen M2116University Medicine Greifswald 97237000
6 · The paper itself

Abstract

(1) Background: High-risk neuroblastoma (HR-NB) is associated with a poor prognosis despite a multimodal high-intensity treatment regimen, including immunotherapy with anti-GD2 monoclonal antibodies (mAb). Here, we investigated the effects of an anti-idiotypic vaccine based on the mAb ganglidiomab that structurally mimics GD2. (2) Methods: Patients with HR-NB treated with anti-GD2 mAb dinutuximab beta and who achieved complete remission after frontline or salvage therapy were offered the vaccine (0.5 mg ganglidiomab adsorbed to Alhydrogel

Indexed as

ganglioside GD2immunotherapyneuroblastomavaccine

Identifiers

PMID36497290
PMCPMC9735439
OpenAlexW4310172310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.