Evidence map›Paper›PMID 36497134›Full record

ArticleCells2022

Development of a Lung Vacancy Mouse Model through CRISPR/Cas9-Mediated Deletion of Thyroid Transcription Factor 1 Exon 2.

Lihua Zhao, Meishuang Li, Zhibao Yin, Limin Lv, Meng Zhou, Yixi Wang, Manling Zhang, Tianxu Guo, Xiyun Guo, Han Liu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lihua ZhaoJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China.
Meishuang LiJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China.
Zhibao YinJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China.
Limin LvLaboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Meng ZhouJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China.
Yixi WangLaboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-9705-7964
Manling ZhangJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China.
Tianxu GuoJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China.
Xiyun GuoJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China.
Han LiuJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China.
Linxin ChengJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China.
Xiubin LiangDepartment of Pathophysiology, Nanjing Medical University, Nanjing 211166, China.
Shuguang DuoLaboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Rongfeng LiJiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing 211166, China.ORCID 0000-0002-9624-3706
Nanjing Medical University · CNChinese Academy of Sciences · CN

Funding

National Natural Science Foundation of China 31971379
6 · The paper itself

Abstract

A developmental niche vacancy in host embryos is necessary for stem cell complementation-based organ regeneration (SCOG). Thyroid transcription factor 1 (TTF-1) is a tissue-specific transcription factor that regulates the embryonic development and differentiation of the thyroid and, more importantly, lungs; thus, it has been considered as a master gene to knockout in order to develop a lung vacancy host.

Indexed as

CRISPR-Cas SystemsThyroid Nuclear Factor 1Tracheoesophageal FistulaAnimalsDisease Models, AnimalFemaleHumansLungMiceMice, KnockoutPregnancyThyroid Nuclear Factor 1CRISPR/Cas9developmental nichelungTTF-1

Identifiers

PMID36497134
PMCPMC9740088
OpenAlexW4310534120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.