Evidence map›Paper›PMID 36496505›Full record

ArticleNature communications2022

An HSV-1-H129 amplicon tracer system for rapid and efficient monosynaptic anterograde neural circuit tracing.

Feng Xiong, Hong Yang, Yi-Ge Song, Hai-Bin Qin, Qing-Yang Zhang, Xian Huang, Wei Jing, Manfei Deng, Yang Liu, Zhixiang Liu and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 26 citations in OpenAlex.

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  8. PVNAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Journal of virology · 2026
    Article
  10. Article
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  12. An Amygdala-hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Feng Xiong *State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Hong Yang *State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Yi-Ge SongDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hai-Bin QinState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Qing-Yang ZhangState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.
Xian HuangDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0003-0164-5727
Wei JingDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Manfei DengDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yang LiuNational Institute of Biological Sciences, Beijing, China.
Zhixiang LiuNational Institute of Biological Sciences, Beijing, China.
Yin ShenEye Center, Renmin Hospital, Wuhan University, Wuhan, China.ORCID http://orcid.org/0000-0002-4201-3948
Yunyun HanEye Center, Renmin Hospital, Wuhan University, Wuhan, China.ORCID http://orcid.org/0000-0003-2336-167X
Youming LuDepartment of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0002-6754-4411
Xiangmin XuDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, USA.
Todd C HolmesCenter for Neural Circuit Mapping, School of Medicine, University of California, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-8152-8832
Minmin LuoNational Institute of Biological Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-3535-6624
Fei ZhaoChinese Institute for Brain Research, Beijing, China. zhaofei@cibr.ac.cn.ORCID http://orcid.org/0000-0003-1393-3734
Min-Hua LuoState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. luomh@wh.iov.cn.ORCID http://orcid.org/0000-0001-9352-0643
Wen-Bo ZengState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. zengwb@wh.iov.cn.ORCID http://orcid.org/0000-0002-1334-2726
Chinese Academy of Sciences · CNHuazhong University of Science and Technology · CNUniversity of California, Irvine · USNational Institute of Biological Sciences, Beijing · CNWuhan University · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monosynaptic viral tracers are essential tools for dissecting neuronal connectomes and for targeted delivery of molecular sensors and effectors. Viral toxicity and complex multi-injection protocols are major limiting application barriers. To overcome these barriers, we developed an anterograde monosynaptic H129

Indexed as

ConnectomeNerve NetHerpesvirus 1, HumanNeurons

Identifiers

PMID36496505
PMCPMC9741617
OpenAlexW4311678728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.