Evidence map›Paper›PMID 36496421›Full record

ArticleRespiratory research2022

D-Limonene inhibits the occurrence and progression of LUAD through suppressing lipid droplet accumulation induced by PM

Tengteng Zhu, Yangyang Li, Tienan Feng, Yuqing Yang, Kai Zhang, Jing Gao, Xiaowei Quan, Ying Qian, Herbert Yu, Biyun Qian

Open access · goldAbstract read
In one paragraph

Article in Respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Applications of Limonene in Neoplasms and Non-Neoplastic Diseases.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Particulate matter-induced epigenetic modifications and lung complications.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Tengteng Zhu *School of Public Health, Shanghai Tongren Hospital, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200052, China.
Yangyang Li *School of Public Health, Shanghai Tongren Hospital, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200052, China.
Tienan Feng *School of Public Health, Shanghai Tongren Hospital, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200052, China.
Yuqing YangShanghai Huangpu District Center for Disease Control and Prevention, Shanghai, 200002, China.
Kai ZhangSchool of Public Health, Shanghai Tongren Hospital, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200052, China.
Jing GaoSchool of Public Health, Shanghai Tongren Hospital, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200052, China.
Xiaowei QuanSchool of Public Health, Shanghai Tongren Hospital, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200052, China.
Ying QianSchool of Public Health, Shanghai Tongren Hospital, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200052, China.
Herbert YuCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 999203, USA.
Biyun QianSchool of Public Health, Shanghai Tongren Hospital, Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200052, China. qianbiyun@sjtu.edu.cn.
Tongren Hospital · CNShanghai Jiao Tong University · CNShanghai Hospital Development Center · CNUniversity of Hawaii System · US

Funding

National Natural Science Foundation of China 81973135Science and Technology Commission of Shanghai Municipality 21XD1402600SJTU Medicine-Engineering Research Fund YG2019QNA71
6 · The paper itself

Abstract

backgroundPM

methodsElectron microscopy and oil-red staining were conducted to examine the lipid droplet accumulation. Masson's trichrome staining, colony forming, scratch assay and transwell experiment were conducted to evaluate the effect of PM

resultsOur results showed that PM

conclusionOur findings reveal a new mechanism of pulmonary fibrosis and LUAD that is related to PM

Indexed as

Adenocarcinoma of LungLung NeoplasmsMicroRNAsPulmonary FibrosisAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansLimoneneLipid DropletsMiceLimoneneMicroRNAsCancer preventionDe novo lipogenesisD-LimoneneLipid dropletLung adenocarcinomaPM2.5

Identifiers

PMID36496421
PMCPMC9741803
OpenAlexW4311663565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.