Evidence map›Paper›PMID 36496282›Full record

ArticleVaccine2023

A case-crossover study of the effect of vaccination on SARS-CoV-2 transmission relevant behaviours during a period of national lockdown in England and Wales.

Aimee Serisier, Sarah Beale, Yamina Boukari, Susan Hoskins, Vincent Nguyen, Thomas Byrne, Wing Lam Erica Fong, Ellen Fragaszy, Cyril Geismar, Jana Kovar and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Aimee SerisierInstitute of Epidemiology and Health Care, University College London, London WC1E 7HB, UK.
Sarah BealeInstitute of Epidemiology and Health Care, University College London, London WC1E 7HB, UK; Centre for Public Health Data Science, Institute of Health Informatics, University College London, NW1 2DA, UK. Electronic address: sarah.beale.19@ucl.ac.uk.
Yamina BoukariCentre for Public Health Data Science, Institute of Health Informatics, University College London, NW1 2DA, UK.
Susan HoskinsInstitute of Epidemiology and Health Care, University College London, London WC1E 7HB, UK.
Vincent NguyenInstitute of Epidemiology and Health Care, University College London, London WC1E 7HB, UK; Centre for Public Health Data Science, Institute of Health Informatics, University College London, NW1 2DA, UK.
Thomas ByrneCentre for Public Health Data Science, Institute of Health Informatics, University College London, NW1 2DA, UK.
Wing Lam Erica FongCentre for Public Health Data Science, Institute of Health Informatics, University College London, NW1 2DA, UK.
Ellen FragaszyCentre for Public Health Data Science, Institute of Health Informatics, University College London, NW1 2DA, UK; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Cyril GeismarInstitute of Epidemiology and Health Care, University College London, London WC1E 7HB, UK; Centre for Public Health Data Science, Institute of Health Informatics, University College London, NW1 2DA, UK.
Jana KovarInstitute of Epidemiology and Health Care, University College London, London WC1E 7HB, UK.
Alexei YavlinskyCentre for Public Health Data Science, Institute of Health Informatics, University College London, NW1 2DA, UK.
Andrew HaywardInstitute of Epidemiology and Health Care, University College London, London WC1E 7HB, UK.
Robert W AldridgeInstitute of Epidemiology and Health Care, University College London, London WC1E 7HB, UK.
Health Data Research UK · GBUniversity College London · GBUniversity of London · GB

Funding

Medical Research Council MC_PC 19,070Medical Research Council MC_PC_19070Medical Research Council MR/N013867/1Medical Research Council MR/V028375/1Wellcome Trust
6 · The paper itself

Abstract

backgroundStudies of COVID-19 vaccine effectiveness show increases in COVID-19 cases within 14 days of a first dose, potentially reflecting post-vaccination behaviour changes associated with SARS-CoV-2 transmission before vaccine protection. However, direct evidence for a relationship between vaccination and behaviour is lacking. We aimed to examine the association between vaccination status and self-reported non-household contacts and non-essential activities during a national lockdown in England and Wales.

methodsParticipants (n = 1154) who had received the first dose of a COVID-19 vaccine reported non-household contacts and non-essential activities from February to March 2021 in monthly surveys during a national lockdown in England and Wales. We used a case-crossover study design and conditional logistic regression to examine the association between vaccination status (pre-vaccination vs 14 days post-vaccination) and self-reported contacts and activities within individuals. Stratified subgroup analyses examined potential effect heterogeneity by sociodemographic characteristics such as sex, household income or age group.

results457/1154 (39.60 %) participants reported non-household contacts post-vaccination compared with 371/1154 (32.15 %) participants pre-vaccination. 100/1154 (8.67 %) participants reported use of non-essential shops or services post-vaccination compared with 74/1154 (6.41 %) participants pre-vaccination. Post-vaccination status was associated with increased odds of reporting non-household contacts (OR 1.65, 95 % CI 1.31-2.06, p < 0.001) and use of non-essential shops or services (OR 1.50, 95 % CI 1.03-2.17, p = 0.032). This effect varied between men and women and different age groups.

conclusionParticipants had higher odds of reporting non-household contacts and use of non-essential shops or services within 14 days of their first COVID-19 vaccine compared to pre-vaccination. Public health emphasis on maintaining protective behaviours during this post-vaccination time period when individuals have yet to develop full protection from vaccination could reduce risk of SARS-CoV-2 infection.

Indexed as

COVID-19SARS-CoV-2Communicable Disease ControlCOVID-19 VaccinesCross-Over StudiesEnglandFemaleHumansMaleSelf ReportVaccinationWalesCOVID-19 VaccinesBehaviourCOVID-19MitigationsVaccine

Identifiers

PMID36496282
PMCPMC9721283
OpenAlexW4313489002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.