Evidence map›Paper›PMID 36496176›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2023

Long-term peridialytic blood pressure changes are related to mortality.

Camiel L M de Roij van Zuijdewijn, Paul A Rootjes, Menso J Nubé, Michiel L Bots, Bernard Canaud, Peter J Blankestijn, Frans J van Ittersum, Francisco Maduell, Marion Morena, Sanne A E Peters and 4 more

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Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Camiel L M de Roij van ZuijdewijnAmsterdam UMC, location Vrije Universiteit Amsterdam, Nephrology, Amsterdam, The Netherlands.ORCID 0000-0002-6369-8341
Paul A RootjesAmsterdam UMC, location Vrije Universiteit Amsterdam, Nephrology, Amsterdam, The Netherlands.
Menso J NubéAmsterdam UMC, location Vrije Universiteit Amsterdam, Nephrology, Amsterdam, The Netherlands.
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Bernard CanaudCenter of Excellence Medical, Fresenius Medical Care GmbH, Bad Homburg, Germany.
Peter J BlankestijnDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Frans J van IttersumAmsterdam UMC, location Vrije Universiteit Amsterdam, Nephrology, Amsterdam, The Netherlands.
Francisco MaduellDepartment of Nephrology, Hospital Clinic, Barcelona, Spain.
Marion MorenaPhyMedExp, INSERM, CNRS, University of Montpellier, Département de Biochimie et Hormonologie, CHU Montpellier, Montpellier, France.
Sanne A E PetersGeorge Institute for Global Health, University of Oxford, Oxford, UK.
Andrew DavenportRoyal Free Hospital, University College London Medical School, London, UK.
Robin W M VernooijJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Muriel P C GrootemanAmsterdam UMC, location Vrije Universiteit Amsterdam, Nephrology, Amsterdam, The Netherlands.
HDF Pooling Project investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn chronic haemodialysis (HD) patients, the relationship between long-term peridialytic blood pressure (BP) changes and mortality has not been investigated.

methodsTo evaluate whether long-term changes in peridialytic BP are related to mortality and whether treatment with HD or haemodiafiltration (HDF) differs in this respect, the combined individual participant data of three randomized controlled trials comparing HD with HDF were used. Time-varying Cox regression and joint models were applied.

resultsDuring a median follow-up of 2.94 years, 609 of 2011 patients died. As for pre-dialytic systolic BP (pre-SBP), a severe decline (≥21 mmHg) in the preceding 6 months was independently related to increased mortality [hazard ratio (HR) 1.61, P = .01] when compared with a moderate increase. Likewise, a severe decline in post-dialytic diastolic BP (DBP) was associated with increased mortality (adjusted HR 1.96, P < .0005). In contrast, joint models showed that every 5-mmHg increase in pre-SBP and post-DBP during total follow-up was related to reduced mortality (adjusted HR 0.97, P = .01 and 0.94, P = .03, respectively). No interaction was observed between BP changes and treatment modality.

conclusionSevere declines in pre-SBP and post-DBP in the preceding 6 months were independently related to mortality. Therefore peridialytic BP values should be interpreted in the context of their changes and not solely as an absolute value.

Indexed as

HemodiafiltrationHypertensionBlood PressureHumansProportional Hazards ModelsRenal Dialysisblood pressurehaemodiafiltrationhaemodialysisjoint modelslong-term changesmortality

Identifiers

PMID36496176
PMCPMC10469106

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.