Evidence map›Paper›PMID 36496073›Full record

ArticleThe Journal of biological chemistry2023

hERG1 channel subunit composition mediates proton inhibition of rapid delayed rectifier potassium current (I

Chiamaka U Ukachukwu, Eric N Jimenez-Vazquez, Abhilasha Jain, David K Jones

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Sudden Death-AssociatedbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chiamaka U UkachukwuDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Eric N Jimenez-VazquezDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Abhilasha JainDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
David K JonesDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Internal Medicine, University of Michigan Medical School. Electronic address: davekj@umich.edu.
University of Michigan · US

Funding

INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
Training Program in Translational Cardiovascular Research and EntrepreneurshipT32HL125242 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MICHELE, DANIEL E · 2015 to 2024
$1.9M
Domain-specific gating modulation to restore action potential duration in long QT patient-derived cardiomyocytesR00HL133482 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JONES, DAVID K. · 2018 to 2020
$735k
NHLBI NIH HHS R00 HL133482NHLBI NIH HHS T32 HL125242NIGMS NIH HHS T32 GM007767
6 · The paper itself

Abstract

The voltage-gated channel, hERG1, conducts the rapid delayed rectifier potassium current (I

Indexed as

Electric ConductivityERG1 Potassium ChannelInduced Pluripotent Stem CellsMyocytes, CardiacPotassiumProtein SubunitsProtonsAcidosisDown-RegulationEther-A-Go-Go Potassium ChannelsExtracellular SpaceHumansRNA, MessengerERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsKCNH1 protein, humanPotassiumProtein SubunitsProtonsRNA, MessengeracidosishERGhERG1ahERG1bI(Kr)iPSC-CMsPAS domain

Identifiers

PMID36496073
PMCPMC9867984
OpenAlexW4311086876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.