Evidence map›Paper›PMID 36495954›Full record

ReviewClinical biochemistry2023

Taking a step back from testing: Preanalytical considerations in molecular infectious disease diagnostics.

Stephanie Conrad, Anastasia Gant Kanegusuku, Steven E Conklin

Abstract readReview
In one paragraph

Review in Clinical biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. The protective effects of the combination ofOpen veterinary journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephanie ConradDepartment of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA, USA.
Anastasia Gant KanegusukuDepartment of Pathology, University of Chicago, Chicago, IL, USA.
Steven E ConklinDepartment of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA, USA; Department of Anatomic & Clinical Pathology, Tufts University School of Medicine, Boston, MA, USA. Electronic address: sconklinlopez@tuftsmedicalcenter.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies evaluating the preanalytical factors that impact the outcome of nucleic-acid based methods for the confirmation of SARS-CoV-2 have illuminated the importance of identifying variables that promoted accurate testing, while using scarce resources efficiently. The majority of laboratory errors occur in the preanalytical phase. While there are many resources identifying and describing mechanisms for main laboratory testing on automated platforms, there are fewer comprehensive resources for understanding important preanalytical and environmental factors that affect accurate molecular diagnostic testing of infectious diseases. This review identifies evidence-based factors that have been documented to impact the outcome of nucleic acid-based molecular techniques for the diagnosis of infectious diseases.

Indexed as

Clinical Laboratory TechniquesCOVID-19COVID-19 TestingHumansPre-Analytical PhaseSARS-CoV-2Specimen HandlingInfectious diseaseMolecular diagnosticsPreanalytics

Identifiers

PMID36495954
PMCPMC9729171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.