ArticleJournal of clinical monitoring and computing2023
Exploring the relationship between capillary refill time, skin blood flow and microcirculatory reactivity during early resuscitation of patients with septic shock: a pilot study.
Article in Journal of clinical monitoring and computing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis.Critical care (London, England) · 2023Pooled it
- The evolution of sepsis care: from protocol-driven management to personalized intensive care.Infection · 2026Review
- Beyond blood pressure: a comprehensive overview of clinical indices in shock and tissue hypoperfusion.Acute and critical care · 2026Article
- Acute hemodynamic tests to determine the status of macro-to-microcirculatory coupling during septic shock resuscitation.Critical care (London, England) · 2026Article
- Thermal intervention improves pulse oximetry accuracy in critically ill patients with low perfusion: a quasi-experimental study.Journal of intensive care · 2026Article
- Lactate in cardiogenic shock: pathophysiology, prognostic value, and clinical interpretation.Annals of intensive care · 2026Review
- Evaluating local ischemic preconditioning effects on skin perfusion using capillary refill time in healthy volunteers.Journal of clinical monitoring and computing · 2025Article
- Observational Study of Sublingual Microcirculation in Patients With Chronic Cardiovascular Disease.Microcirculation (New York, N.Y. : 1994) · 2025Observational
- The intricate relationship between capillary refill time and systemic hemodynamics in septic shock.Annals of intensive care · 2025Review
- Capillary refill time and tissue oxygen saturation as factors influencing lower limb ischemia in VA-ECMO: a case-control study.BMC cardiovascular disorders · 2025Article
- Relationship between skin microvascular blood flow and capillary refill time in critically ill patients.Critical care (London, England) · 2025Observational
- A New Approach to Non-Invasive Microcirculation Monitoring: Quantifying Capillary Refill Time Using Oximetric Pulse Waves.Sensors (Basel, Switzerland) · 2025Article
- Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method.Intensive care medicine · 2025Review
- Research Progress on the Measurement Methods and Clinical Significance of Capillary Refill Time.Sensors (Basel, Switzerland) · 2024Review
- Monitoring capillary refill time in septic shock.Intensive care medicine · 2024Article
- Capillary refill time response to a fluid challenge or a vasopressor test: an observational, proof-of-concept study.Annals of intensive care · 2024Article
- Effect on capillary refill time of volume expansion and increase of the norepinephrine dose in patients with septic shock.Critical care (London, England) · 2023Observational
- Transfusion increased skin blood flow when initially low in volume-resuscitated patients without acute bleeding.Frontiers in medicine · 2023Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 4 countries.
Funding
Abstract
Capillary refill time (CRT), a costless and widely available tool, has emerged as a promising target to guide septic shock resuscitation. However, it has yet to gain universal acceptance due to its potential inter-observer variability. Standardization of CRT assessment may minimize this problem, but few studies have compared this approach with techniques that directly assess skin blood flow (SBF). Our objective was to determine if an abnormal CRT is associated with impaired SBF and microvascular reactivity in early septic shock patients. Twelve septic shock patients were subjected to multimodal perfusion and hemodynamic monitoring for 24 h. Three time-points (0, 1, and 24 h) were registered for each patient. SBF was measured by laser doppler. We performed a baseline SBF measurement and two microvascular reactivity tests: one with a thermal challenge at 44 °C and other with a vascular occlusion test. Ten healthy volunteers were evaluated to obtain reference values. The patients (median age 70 years) exhibited a 28-day mortality of 50%. Baseline CRT was 3.3 [2.7-7.3] seconds. In pooled data analysis, abnormal CRT presented a significantly lower SBF when compared to normal CRT [44 (13.3-80.3) vs 193.2 (99.4-285) APU, p = 0.0001]. CRT was strongly associated with SBF (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.