Evidence map›Paper›PMID 36495329›Full record

ArticleJournal of cancer research and clinical oncology2023

Impact of patient nationality on the severity of early side effects after radiotherapy.

Mümtaz Köksal, Romy Streppel, Stefan Hauser, Alina Abramian, Christina Kaiser, Maria Gonzalez-Carmona, Georg Feldmann, Niklas Schäfer, Sebastian Koob, Mohammed Banat and 3 more

Abstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mümtaz KöksalDepartment of Radiation Oncology, University Medical Center Bonn (UKB), Bonn, Germany. muemtaz.koeksal@ukbonn.de.
Romy StreppelDepartment of Radiation Oncology, University Medical Center Bonn (UKB), Bonn, Germany.
Stefan HauserDepartment of Urology, University Medical Center Bonn (UKB), Bonn, Germany.
Alina AbramianDepartment of Senology and Breast Center, University Medical Center Bonn (UKB), Bonn, Germany.
Christina KaiserDepartment of Senology and Breast Center, University Medical Center Bonn (UKB), Bonn, Germany.
Maria Gonzalez-CarmonaDepartment of Internal Medicine, University Medical Center Bonn (UKB), Bonn, Germany.
Georg FeldmannDepartment of Internal Medicine, University Medical Center Bonn (UKB), Bonn, Germany.
Niklas SchäferDepartment of Neuro-Oncology, University Medical Center Bonn (UKB), Bonn, Germany.
Sebastian KoobDepartment of Orthopedic Surgery, University Medical Center Bonn (UKB), Bonn, Germany.
Mohammed BanatDepartment of Neurosurgery, University Medical Center Bonn (UKB), Bonn, Germany.
Motaz HamedDepartment of Neurosurgery, University Medical Center Bonn (UKB), Bonn, Germany.
Frank A GiordanoDepartment of Radiation Oncology, University Medical Center Mannheim (UMM), Mannheim, Germany.
Leonard C SchmeelDepartment of Radiation Oncology, University Medical Center Bonn (UKB), Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMajor demographical changes in Germany commenced in the 1960s. Ongoing humanitarian crises in the Ukraine with subsequent immigration will have also long-range effects on national provision of cancer treatment. Ensuring the best possible outcomes for each cancer patient undergoing radiotherapy requires the prediction and prevention of unfavorable side effects. Given that recent research has primarily focused on clinical outcome indicators solely, less is known regarding sociodemographic predictors of therapeutic outcomes, such as patient nationality. Here, we investigated whether the severity of early side effects after radiotherapy are associated with patient nationality and other sociodemographic and clinical characteristics.

methodsOut of 9187 patients treated at a German university medical center between 2017 and 2021, 178 German and 178 non-German patients were selected for matched-pair analysis based on diagnostic and demographic criteria. For all 356 patients, data on side effects from follow-up care after radiotherapy were collected.

resultsNon-German patients were more likely to have severe side effects than German patients. Side effect severity was also associated with tumor entity, concomitant therapy, body mass index, and age.

conclusionForeign cancer patients are at higher risk of experiencing severe side effects of radiotherapy, suggesting a need to develop and implement targeted preventive measures for these patients. Further research investigating factors predicting the occurrence of radiotherapy side effects, including other sociodemographic characteristics, is needed to better personalize therapy regimens for cancer.

Indexed as

Drug-Related Side Effects and Adverse ReactionsNeoplasmsEthnicityGermanyHumansPatientsRadiotherapyImmigrationPersonalize therapyPreventive medicineRadiation therapySide effects

Identifiers

PMID36495329
PMCPMC10356627

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.