Observational studyScandinavian journal of trauma, resuscitation and emergency medicine2022
Implementation of a low-titre whole blood transfusion program in a civilian helicopter emergency medical service.
Observational study in Scandinavian journal of trauma, resuscitation and emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02784951 (Use of Blood and Plasma in Prehospital Haemorrhagic Shock - a Prospective, Observational Trial of Advanced Deployment of Blood Products in Norwegian Physician-staffed Helicopter Emergency Medical System), which is not on this map. Cited by 8 papers.
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The trial behind it
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Use of Blood and Plasma in Prehospital Haemorrhagic Shock - a Prospective, Observational Trial of Advanced Deployment of Blood Products in Norwegian Physician-staffed Helicopter Emergency Medical System
Who cites it
8 citing papers in PubMed.
- Revised french military transfusion doctrine for large-scale combat operations: a consensus framework.Critical care (London, England) · 2026Review
- The Feasibility and Safety of Prehospital Whole Blood Administration for Patients in Hemorrhagic Shock in Isolated Regions of Colorado: Assessment of the First 6 Months.World journal of surgery · 2026Article
- Practices in platelet production: A Nordic perspective (2018-2022).Vox sanguinis · 2026Article
- A full response chain surge capacity test of a small rural hospital, prehospital resources and collaborating organisations.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- [Prehospital blood transfusion : Opportunities and challenges for the German emergency medical services].Die Anaesthesiologie · 2024Review
- Current trends in the management of out of hospital cardiac arrest (OHCA).Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2024Review
- Characteristics of the most severely ill and injured patients in a Norwegian helicopter emergency medical service: a retrospective cohort study.BMC emergency medicine · 2024Article
- Blood failure: traumatic hemorrhage and the interconnections between oxygen debt, endotheliopathy, and coagulopathy.Clinical and experimental emergency medicine · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly balanced transfusion is associated with improved outcome in haemorrhagic shock patients. This study describes the implementation and evaluates the safety of a whole blood transfusion program in a civilian helicopter emergency medical service (HEMS).
methodsThis prospective observational study was performed over a 5-year period at HEMS-Bergen, Norway. Patients in haemorrhagic shock receiving out of hospital transfusion of low-titre Group O whole blood (LTOWB) or other blood components were included. Two LTOWB units were produced weekly and rotated to the HEMS for forward storage. The primary endpoints were the number of patients transfused, mechanisms of injury/illness, adverse events and survival rates. Informed consent covered patient pathway from time of emergency interventions to last endpoint and subsequent data handling/storage.
resultsThe HEMS responded to 5124 patients. Seventy-two (1.4%) patients received transfusions. Twenty patients (28%) were excluded due to lack of consent (16) or not meeting the inclusion criteria (4). Of the 52 (100%) patients, 48 (92%) received LTOWB, nine (17%) received packed red blood cells (PRBC), and nine (17%) received freeze-dried plasma. Of the forty-six (88%) patients admitted alive to hospital, 35 (76%) received additional blood transfusions during the first 24 h. Categories were blunt trauma 30 (58%), penetrating trauma 7 (13%), and nontrauma 15 (29%). The majority (79%) were male, with a median age of 49 (IQR 27-70) years. No transfusion reactions, serious complications or logistical challenges were reported. Overall, 36 (69%) patients survived 24 h, and 28 (54%) survived 30 days.
conclusionsImplementing a whole blood transfusion program in civilian HEMS is feasible and safe and the logistics around out of hospital whole blood transfusions are manageable. Trial registration The study is registered in the ClinicalTrials.gov registry (NCT02784951).
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