Evidence map›Paper›PMID 36494653›Full record

ArticleBMC oral health2022

Traumatic temporomandibular joint bony ankylosis in growing rats.

Zhen Ma, Yiming Wang, Yang Xue, Wuyang Zhang, Dengke Li, Yuan Li, Guowei Li, Hongzhi Zhou, Xiangxiang Hu, Tiange Deng and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Zhen Ma *State Key Laboratory of Military Stomatology, National Clinical Research and Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases and Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, China.
Yiming Wang *State Key Laboratory of Military Stomatology, National Clinical Research and Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases and Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, China.
Yang XueState Key Laboratory of Military Stomatology, National Clinical Research and Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases and Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, China.
Wuyang ZhangState Key Laboratory of Military Stomatology, National Clinical Research and Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases and Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, China.
Dengke LiState Key Laboratory of Military Stomatology, National Clinical Research and Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases and Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, China.
Yuan LiState Key Laboratory of Military Stomatology, National Clinical Research and Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases and Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, China.
Guowei LiState Key Laboratory of Military Stomatology, National Clinical Research and Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases and Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, China.
Hongzhi ZhouState Key Laboratory of Military Stomatology, National Clinical Research and Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases and Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, China.
Xiangxiang Hu *Division of Oral and Craniofacial Health Sciences, University of North Carolina Adams School of Dentistry, Chapel Hill, NC, 27514, USA. allenhu@unc.edu.
Tiange Deng *State Key Laboratory of Military Stomatology, National Clinical Research and Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases and Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, China. dtgyszc@163.com.
Kaijin Hu *State Key Laboratory of Military Stomatology, National Clinical Research and Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases and Department of Oral Surgery, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi'an, 710032, China. hukaijin2015@126.com.
Air Force Medical University · CNUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pathogenesis of traumatic temporomandibular joint (TMJ) bony ankylosis remains unknown. This study aimed to explore the pathogenesis of traumatic TMJ bony ankylosis in a rat model.

methodsTwenty-four 3-week-old male Sprague-Dawley rats were used in this study. Excision of the whole disc, the fibrocartilage damage of the condyle and glenoid fossa, and narrowed joint space were performed in the left TMJ of the operation group to induce TMJ bony ankylosis (experimental side). The right TMJ underwent a sham operation (sham side). The control group did not undergo any operations. At 1, 4, and 8 weeks postoperatively, rats of the operation group were sacrificed and TMJ complexes were evaluated by gross observation, Micro-CT, histological examinations, and immunofluorescence microscopy. Total RNA of TMJ complexes in the operation group were analyzed using RNA-seq.

resultsGross observations revealed TMJ bony ankylosis on the experimental side. Micro-CT analysis demonstrated that compared to the sham side, the experimental side showed a larger volume of growth, and a considerable calcified bone callus formation in the narrowed joint space and on the rougher articular surfaces. Histological examinations indicated that endochondral ossification was observed on the experimental side, but not on the sham side. RNA-seq analysis and immunofluorescence revealed that Matrix metallopeptidase 13 (MMP13) and Runt-related transcription factor 2 (RUNX2) genes of endochondral ossification were significantly more downregulated on the experimental side than on the sham side. The primary pathways related to endochondral ossification were Parathyroid hormone synthesis, secretion and action, Relaxin signaling pathway, and IL-17 signaling pathway.

conclusionsThe present study provided an innovative and reliable rat model of TMJ bony ankylosis by compound trauma and narrowed joint space. Furthermore, we demonstrated the downregulation of MMP13 and RUNX2 in the process of endochondral ossification in TMJ bony ankylosis.

Indexed as

AnkylosisMandibular CondyleAnimalsMaleRatsRats, Sprague-DawleyTemporomandibular JointTemporomandibular Joint DisordersCompound traumaEndochondral ossificationJoint spacematrix metallopeptidase 13Runt-related transcription factor 2Temporomandibular joint bony ankylosis

Identifiers

PMID36494653
PMCPMC9733295
OpenAlexW4311672104

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.