Evidence map›Paper›PMID 36494632›Full record

ArticleBMC infectious diseases2022

Biofilm infection of a central venous port-catheter caused by Mycobacterium avium complex in an immunocompetent child with cystic fibrosis.

Alexandra Kavvalou, Florian Stehling, Eva Tschiedel, Jan Kehrmann, Bernd Walkenfort, Mike Hasenberg, Margarete Olivier, Mathis Steindor

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Respirology case reports · 2024
    Article
  2. The State-of-the-Art ofHealthcare (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alexandra KavvalouDepartment of Pediatric Pulmonology and Sleep Medicine, University Hospital Essen, Children's Hospital, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany. alexandra.kavvalou@uk-essen.de.ORCID http://orcid.org/0000-0002-2388-4043
Florian StehlingDepartment of Pediatric Pulmonology and Sleep Medicine, University Hospital Essen, Children's Hospital, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Eva TschiedelDepartment of Pediatric Intensive Care, Children's Hospital, University of Duisburg-Essen, Essen, Germany.
Jan KehrmannInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Bernd WalkenfortInstitute for Experimental Immunology and Imaging, Imaging Center Essen, Electron Microscopy Unit (EMU), University of Duisburg-Essen, Essen, Germany.
Mike HasenbergInstitute for Experimental Immunology and Imaging, Imaging Center Essen, Electron Microscopy Unit (EMU), University of Duisburg-Essen, Essen, Germany.
Margarete OlivierDepartment of Pediatric Pulmonology and Sleep Medicine, University Hospital Essen, Children's Hospital, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Mathis SteindorDepartment of Pediatric Pulmonology and Sleep Medicine, University Hospital Essen, Children's Hospital, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
University of Duisburg-Essen · DEEssen University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMycobacterium (M.) chimaera is a non-tuberculous mycobacterium (NTM) that belongs to M. avium complex (MAC). In patients with cystic fibrosis (CF), MAC can cause bronchopulmonary infections that can be prolonged and difficult to treat. MAC infections of sites other than the lungs or central catheters are rare and almost exclusively associated with immunodeficiency. CASE PRESENTATION: We present a case of an 8-year-old CF patient (delF508 homozygous) with recurrent pulmonary exacerbations, gradual clinical deterioration, B-symptoms (fever, fatigue, weight loss, night sweat), elevated transaminases and intermittent detection of M. chimaera in the sputum without radiological signs of NTM-associated lung disease with a central venous port-catheter. Next-generation sequencing (NGS) revealed M. chimaera port infection that was also confirmed by mycobacterial culture. The patient recovered within 4 weeks after removal of the catheter and initiation of MAC targeted antimicrobial therapy. Electron microscopy of the catheter illustrated the presence of mycobacteria in a biofilm.

conclusionsMAC central venous catheter infection needs to be considered in immunocompetent people. NGS is a valuable tool for rapid identification of rare infections. MAC capability of biofilm formation renders catheter removal the central therapeutic intervention for the clearance of the infection.

Indexed as

Central Venous CathetersCystic FibrosisMycobacteriumMycobacterium avium-intracellulare InfectionMycobacterium Infections, NontuberculousChildHumansMycobacterium avium ComplexNontuberculous MycobacteriaSputumBiofilm infectionCystic fibrosisMAC

Identifiers

PMID36494632
PMCPMC9733094
OpenAlexW4311674410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.