ArticleCommunications biology2022
Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 43 citations in OpenAlex.
- Phytohormone-Assisted Bioprocess Engineering for Enhanced Omega Fatty Acid Production in Marine Thraustochytrids Under Cold Stress Conditions.Marine biotechnology (New York, N.Y.) · 2026Article
- PolyphasicFrontiers in nutrition · 2026Article
- Omega-3 Source Matters: Comparative Lipid Signatures and Quantitative Distribution of EPA/DHA Across Marine Resources.Marine drugs · 2025Article
- Effects of DpWRI1-like gene overexpression in transgenic Dunaliella parva.Antonie van Leeuwenhoek · 2025Article
- Mixtures of Algal Oil and Terrestrial Oils in Diets of Tiger Puffer (Animals : an open access journal from MDPI · 2025Article
- Sulfo-phospho-vanillin method for screening Aurantiochytrium strains with high docosahexaenoic acid levels.AMB Express · 2025Article
- Engineering Fatty Acid Biosynthesis in Microalgae: Recent Progress and Perspectives.Marine drugs · 2024Review
- Transcriptomics aids in uncovering the metabolic shifts and molecular machinery of Schizochytrium limacinum during biotransformation of hydrophobic substrates to docosahexaenoic acid.Microbial cell factories · 2024Article
- Simultaneous DHA and organic selenium production by Schizochytrium sp.: a theoretical basis.Scientific reports · 2023Article
- Transcriptome Analysis Reveals an Eicosapentaenoic Acid Accumulation Mechanism in aMicrobiology spectrum · 2023Article
- Screening and Identification of Coastal Chilean Thraustochytrids for Arachidonic Acid Production: Biotechnological Potential ofMicroorganisms · 2023Article
- Immunomodulatory effect of marine lipids on food allergy.Frontiers in nutrition · 2023Review
- Biotechnological production of omega-3 fatty acids: current status and future perspectives.Frontiers in microbiology · 2023Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Presently, the supply of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) traditionally produced by marine fisheries will be insufficient to meet their market demand in food industry. Thus a sustainable alternative source is urgently required. Schizochytrium sp. is an ideal producer of DHA; however, its ability to co-produce DHA and EPA has not yet been proved. Herein, we first described a cobalamin-independent methionine synthase-like (MetE-like) complex, which contains independent acyltransferase and 3-ketoacyl synthase domains, independent of the traditional polyketide synthase (PKS) system. When the MetE-like complex was activated, the EPA content was increased from 1.26% to 7.63%, which is 6.06-folds higher than that in the inactivated condition. Through lipidomics, we find that EPA is more inclined to be stored as triglyceride. Finally, the EPA production was enhanced from 4.19 to 29.83 (mg/g cell dry weight) using mixed carbon sources, and the final yield reached 2.25 g/L EPA and 9.59 g/L DHA, which means that Schizochytrium sp. has great market potential for co-production of EPA and DHA.
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