ArticleScientific reports2022
Resting state functional connectivity as a marker of internalizing disorder onset in high-risk youth.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Connectome-based prediction of problematic use of social media in adolescents: Findings from the ABCD study.NeuroImage · 2026Article
- Life experiences of humiliation, entrapment, and frontoparietal-cerebellar connectivity predict adolescent anxiety and depression symptoms.Psychological medicine · 2026Article
- Article
- Subcortical resting state functional connectivity as a neural marker of first onset internalizing disorder in high-risk youth.Neuroimage. Reports · 2025Article
- Shared and unique lifetime stressor characteristics and network connectivity predict adolescent anxiety and depression.bioRxiv : the preprint server for biology · 2025Article
- Sex and age differences on how testosterone relates to brain activity during working memory among adolescents and young adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Intrinsic functional brain connectivity in adolescent anxiety: Associations with behavioral phenotypes and cross-syndrome network features.Journal of affective disorders · 2025Article
- Altered local gyrification index and corresponding functional connectivity in female depressed adolescents with suicide attempts and non-suicidal self-injury.Psychoradiology · 2025Article
- Neuro-functional correlates of personality dimensions in Parkinson's disease.Frontiers in pharmacology · 2025Article
- Higher amplitudes of visual networks are associated with trait- but not state-depression.Psychological medicine · 2024Article
- Associations between parental psychopathology and youth functional emotion regulation brain networks.Developmental cognitive neuroscience · 2024Article
- Frequency specificity of aberrant triple networks in major depressive disorder: a resting-state effective connectivity study.Frontiers in neuroscience · 2023Article
- The longitudinal impact of screen media activities on brain function, architecture and mental health in early adolescence.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
3 authors.
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Abstract
While research has linked alterations in functional connectivity of the default mode (DMN), cognitive control (CCN), and salience networks (SN) to depression and anxiety, little research has examined whether these alterations may be premorbid vulnerabilities. This study examined resting state functional connectivity (RSFC) of the CCN, DMN, and SN as markers of risk for developing an onset of a depressive or anxiety disorder in adolescents at high familial risk for these disorders. At baseline, 135 participants aged 11-17 completed resting-state functional magnetic resonance imaging, measures of internalizing symptoms, and diagnostic interviews to assess history of depressive and anxiety disorders. Diagnostic assessments were completed again at 9- or 18-month follow-up for 112 participants. At baseline, increased CCN connectivity to areas of the visual network, and decreased connectivity between the left SN and the precentral gyrus, predicted an increased likelihood of a new onset at follow-up. Increased connectivity between the right SN and postcentral gyrus at baseline predicted first episode onsets at follow-up. Altered connectivity between these regions may represent a risk factor for developing a clinically significant onset of an internalizing disorder. Results may have implications for understanding the neural bases of internalizing disorders for early identification and prevention efforts.
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