ReviewNature protocols2023
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice.
Review in Nature protocols, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Targeting Cystine Addiction Suppresses Breast Cancer Lung Metastasis.Cancer research · 2026Article
- Review of image segmentation techniques for biomedical micro-CT: from laboratory absorption imaging to synchrotron phase-contrast.Npj imaging · 2026Review
- Protocol for Post-Mortem Micro-CT Imaging of Coronary Arteries in Low-Mass Neonatal Puppy Hearts Using Barium-Based Contrast.Animals : an open access journal from MDPI · 2026Article
- Accuracy of a Novel Desktop Micro-CT Scanner for Direct Digitization of Dental Impressions: A Comparative In Vitro Study.Dentistry journal · 2026Article
- Mapping lung cancer ventilation dynamics using functional imaging and lung mechanics.Disease models & mechanisms · 2025Article
- High-Resolution Quantitative Reconstruction of Microvascular Architectures in Mouse Hepatocellular Carcinoma Models.Cancers · 2025Article
- A Micro-Computed Tomography-Based Simplified Approach to Measure Body Composition, Osteoporosis, and Lung Fibrosis in Mice.Bio-protocol · 2025Article
- Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses.Science advances · 2024Article
- Neutrophil-targeted liposomal platform: A shift in novel approach for early detection and treatment of cancer metastasis.Asian journal of pharmaceutical sciences · 2024Article
- Combining RAS(ON) G12C-selective inhibitor with SHP2 inhibition sensitises lung tumours to immune checkpoint blockade.Nature communications · 2024Article
- CRISPR-Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer.Cancer research · 2024Article
- Image Processing Techniques for Improving Quality of 3D Profile in Digital Holographic Microscopy Using Deep Learning Algorithm.Sensors (Basel, Switzerland) · 2024Article
- Article
- Semi-automated micro-computed tomography lung segmentation and analysis in mouse models.MethodsX · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
X-ray computed tomography is a reliable technique for the detection and longitudinal monitoring of pulmonary nodules. In preclinical stages of diagnostic or therapeutic development, the miniaturized versions of the clinical computed tomography scanners are ideally suited for carrying out translationally-relevant research in conditions that closely mimic those found in the clinic. In this Protocol, we provide image acquisition parameters optimized for low radiation dose, high-resolution and high-throughput computed tomography imaging using three commercially available micro-computed tomography scanners, together with a detailed description of the image analysis tools required to identify a variety of lung tumor types, characterized by specific radiological features. For each animal, image acquisition takes 4-8 min, and data analysis typically requires 10-30 min. Researchers with basic training in animal handling, medical imaging and software analysis should be able to implement this protocol across a wide range of lung cancer models in mice for investigating the molecular mechanisms driving lung cancer development and the assessment of diagnostic and therapeutic agents.
Indexed as
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36494493What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.