ArticleScientific reports2022
Engineered human organ-specific urethra as a functional substitute.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- From Bench to Operating Room: A Comparative Study of Tensile and Puncture Tests in Self-Assembled Constructs with Clinical Feedback.Bioengineering (Basel, Switzerland) · 2026Article
- IGF-1 Increases Collagen Deposition by Dermal Fibroblasts: Applications for Tissue Engineering.Cells · 2026Article
- I-TEP: A Simple and Affordable Method to Measure Permeability in Reconstructed Tissues Combined with DAMO-TSC-Based Urea Assay.Methods and protocols · 2026Article
- Single-staged in vivo co-transplantation of autologous muscular and urothelial micrografts as a composite tissue tube for urogenital reconstruction.Pediatric surgery international · 2026Article
- Electrospun Polycaprolactone/Collagen Scaffolds Enhance Manipulability and Influence the Composition of Self-Assembled Extracellular Matrix.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- Description of the Human Penile Urethra Epithelium.Medicina (Kaunas, Lithuania) · 2025Article
- Comparing the tissue properties of human buccal mucosa and penile skin flap: insights for urethral graft substitution.World journal of urology · 2025Article
- Correction of Significant Urethral Anomalies Using a Tissue-Engineered Human Urethral Substitute: Proof of Concept.International journal of molecular sciences · 2025Article
- Isolation and characterization of epithelial cells and fibroblasts from the human penile urethra.Frontiers in bioengineering and biotechnology · 2025Article
- Impact of Endocrine Disruptors on the Genitourinary Tract.Journal of xenobiotics · 2024Review
- Tissue Engineering for Penile Reconstruction.Bioengineering (Basel, Switzerland) · 2024Review
- Biological Macromolecule-Based Scaffolds for Urethra Reconstruction.Biomolecules · 2023Review
- Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction.Bioengineering (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urologic patients may be affected by pathologies requiring surgical reconstruction to re-establish a normal function. The lack of autologous tissues to reconstruct the urethra led clinicians toward new solutions, such as tissue engineering. Tridimensional tissues were produced and characterized from a clinical perspective. The balance was optimized between increasing the mechanical resistance of urethral-engineered tissue and preserving the urothelium's barrier function, essential to avoid urine extravasation and subsequent inflammation and fibrosis. The substitutes produced using a mix of vesical (VF) and dermal fibroblasts (DF) in either 90%:10% or 80%:20% showed mechanical resistance values comparable to human native bladder tissue while maintaining functionality. The presence of mature urothelium markers such as uroplakins and tight junctions were documented. All substitutes showed similar histological features except for the noticeable decrease in polysaccharide globules for the substitutes made with a higher proportion of DF. The degree of maturation evaluated with electron microscopy was positively correlated with the increased concentration of VF in the stroma. Substitutes produced with VF and at least 10% of DF showed sufficient mechanical resistance to withstand surgeon manipulation and high functionality, which may improve long-term patients' quality of life, representing a great future alternative to current treatments.
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